SKF-96067

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MedKoo CAT#: 526862

CAS#: 115607-61-9

Description: SKF-96067, also known as SK&F-96067, is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. At pH 7.0, SK&F 96067 inhibited K(+)-stimulated ATPase activity competitively with respect to the activating cation K+, with a Ki value of 0.39 +/- 0.05 microM. Under comparable conditions, SK&F 96067 was 32 times more potent as an inhibitor of the gastric (H+ + K+)-ATPase relative to the closely related (Na+ + K+)-ATPase.

Chemical Structure

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SKF-96067
CAS# 115607-61-9
Instruction

Theoretical Analysis

MedKoo Cat#: 526862
Name: SKF-96067
CAS#: 115607-61-9
Chemical Formula: C21H22N2O2
Exact Mass: 334.17
Molecular Weight: 334.419
Elemental Analysis: C, 75.42; H, 6.63; N, 8.38; O, 9.57

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SKF-96067; SKF 96067; SKF96067; SK&F-96067; SK&F 96067; SK&F96067.

IUPAC/Chemical Name: 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline

InChi Key: MAVJDLHBPIXVJL-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22N2O2/c1-4-8-18(24)16-13-22-21-15(10-7-12-19(21)25-3)20(16)23-17-11-6-5-9-14(17)2/h5-7,9-13H,4,8H2,1-3H3,(H,22,23)

SMILES Code: COC1=C2N=CC(C(CCC)=O)=C(NC3=CC=CC=C3C)C2=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 334.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rhoden KJ, Tallini G, Douglas JS. H+-K+ ATPase inhibitors cause relaxation of
guinea pig and human airway smooth muscle in vitro. J Pharmacol Exp Ther. 1996
Mar;276(3):897-903. PubMed PMID: 8786567.


2: Parsons ME, Rushant B, Rasmussen TC, Leach C, Ife RJ, Postius S, Pope AJ.
Properties of the reversible, K(+)-competitive inhibitor of the gastric
(H+/K+)-ATPase, SK&F 97574. II. Pharmacological properties. Biochem Pharmacol.
1995 Nov 9;50(10):1551-6. PubMed PMID: 7503756.


3: Sarges R, Gallagher A, Chambers TJ, Yeh LA. Inhibition of bone resorption by
H+/K(+)-ATPase inhibitors. J Med Chem. 1993 Sep 17;36(19):2828-30. PubMed PMID:
8410997.


4: Moore TD, Metcalf AC, Swagzdis JE, Doyle E. High-performance liquid
chromatographic determination of concentrations of the reversible H+/K+ ATPase
inhibitor SK&F 97574 in plasma. J Chromatogr. 1993 Sep 8;619(1):172-6. PubMed
PMID: 8245159.


5: Pope AJ, Parsons ME. Reversible inhibitors of the gastric H+/K(+)-transporting
ATPase: a new class of anti-secretory agent. Trends Pharmacol Sci. 1993
Sep;14(9):323-5. Review. PubMed PMID: 8249153.


6: Keeling DJ, Malcolm RC, Laing SM, Ife RJ, Leach CA. SK&F 96067 is a
reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. Biochem
Pharmacol. 1991 Jun 21;42(1):123-30. PubMed PMID: 1648919.