SMND-309

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526793

CAS#: 1065559-56-9

Description: SMND-309 is a novel derivate of salvianolic acid B. SMND-309 promotes neuron survival through the activation of the PI3K/Akt/CREB-signalling pathway. SMND-309 protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. SMND-309 promotes angiogenesis in human umbilical vein endothelial cells through activating erythropoietin receptor/STAT3/VEGF pathways.

Chemical Structure

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SMND-309
CAS# 1065559-56-9
Instruction

Theoretical Analysis

MedKoo Cat#: 526793
Name: SMND-309
CAS#: 1065559-56-9
Chemical Formula: C18H14O8
Exact Mass: 358.07
Molecular Weight: 358.302
Elemental Analysis: C, 60.34; H, 3.94; O, 35.72

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SMND-309; SMND 309; SMND309.

IUPAC/Chemical Name: (E)-2-[6-[(E)-2-carboxyethenyl]-2,3-dihydroxyphenyl]-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

InChi Key: OAHRXWZJURTMHG-ACIWFXKJSA-N

InChi Code: InChI=1S/C18H14O8/c19-12-4-1-9(8-14(12)21)7-11(18(25)26)16-10(3-6-15(22)23)2-5-13(20)17(16)24/h1-8,19-21,24H,(H,22,23)(H,25,26)/b6-3+,11-7+

SMILES Code: O=C(O)/C(C1=C(/C=C/C(O)=O)C=CC(O)=C1O)=C/C2=CC=C(O)C(O)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 358.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang Y, Zhang J, Han M, Liu B, Gao Y, Ma P, Zhang S, Zheng Q, Song X. SMND-309 promotes neuron survival through the activation of the PI3K/Akt/CREB-signalling pathway. Pharm Biol. 2016 Feb 24:1-9. [Epub ahead of print] PubMed PMID: 26911316.

2: Zhu H, Zou L, Tian J, Du G, Gao Y. SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. Eur J Pharmacol. 2013 Aug 15;714(1-3):23-31. doi: 10.1016/j.ejphar.2013.05.043. Epub 2013 Jun 11. PubMed PMID: 23764464.

3: Du G, Zhu H, Yu P, Wang H, He J, Ye L, Fu F, Zhang J, Tian J. SMND-309 promotes angiogenesis in human umbilical vein endothelial cells through activating erythropoietin receptor/STAT3/VEGF pathways. Eur J Pharmacol. 2013 Jan 30;700(1-3):173-80. doi: 10.1016/j.ejphar.2012.12.013. Epub 2012 Dec 28. PubMed PMID: 23276662.

4: Hou J, Tian J, Jiang W, Gao Y, Fu F. Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis. Eur J Pharmacol. 2011 Jan 10;650(1):390-5. doi: 10.1016/j.ejphar.2010.10.019. Epub 2010 Oct 20. PubMed PMID: 20969856.

5: Yang J, Zhang G, Tian J, Li C, Jiang W, Xing Y, Zhu H, Hou J, Xu H, Wu J. Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats. Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):317-23. doi: 10.1111/j.1742-7843.2009.00490.x. Epub 2009 Nov 11. PubMed PMID: 19912162.

6: Tian J, Fu F, Li G, Gao Y, Zhang Y, Meng Q, Li C, Liu F. Protections of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury amelioration in cerebral ischemia rats. Phytomedicine. 2009 Aug;16(8):726-33. doi: 10.1016/j.phymed.2009.01.007. Epub 2009 May 28. PubMed PMID: 19481432.

7: Tian J, Fu F, Li G, Wang Y, Gao Y, Liu Z, Zhang S. SMND-309, a novel derivate of salvianolic acid B, ameliorates cerebral infarction in rats: characterization and role. Brain Res. 2009 Mar 31;1263:114-21. doi: 10.1016/j.brainres.2009.01.034. Epub 2009 Jan 31. PubMed PMID: 19368834.

8: Tian J, Li G, Zhang S, Gao Y, Jiang W, Fu F, Liu Z. SMND-309, a novel derivate of salvianolic acid B, attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons. Basic Clin Pharmacol Toxicol. 2009 Feb;104(2):176-84. doi: 10.1111/j.1742-7843.2008.00349.x. Epub 2008 Dec 16. PubMed PMID: 19143749.