Ono 3708

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525786

CAS#: 102191-05-9

Description: Ono-3708 is a potent antagonist of the thromboxane A2/prostaglandin endoperoxide receptor in vitro and in vivo and may be of therapeutic use in preventing cerebral vasospasm. Recent studies suggest that Ono-378 could play an important role in the pathogenesis of thrombosis and that ONO-3708 may have therapeutic advantages in preventing thrombosis.

Chemical Structure

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Ono 3708
CAS# 102191-05-9
Instruction

Theoretical Analysis

MedKoo Cat#: 525786
Name: Ono 3708
CAS#: 102191-05-9
Chemical Formula: C23H37NO4
Exact Mass: 391.27
Molecular Weight: 391.544
Elemental Analysis: C, 70.55; H, 9.52; N, 3.58; O, 16.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ono3708; Ono-3708; Ono 3708

IUPAC/Chemical Name: (Z)-7-((1S,2S,3S,5R)-3-((R)-2-cyclopentyl-2-hydroxyacetamido)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)hept-5-enoic acid

InChi Key: SXHUZJPIRVLMHY-AZPSIHDESA-N

InChi Code: InChI=1S/C23H37NO4/c1-23(2)16-13-18(23)17(11-5-3-4-6-12-20(25)26)19(14-16)24-22(28)21(27)15-9-7-8-10-15/h3,5,15-19,21,27H,4,6-14H2,1-2H3,(H,24,28)(H,25,26)/b5-3-/t16-,17+,18+,19+,21-/m1/s1

SMILES Code: O=C(O)CCC/C=C\C[C@H]1[C@@](C2)([H])C(C)(C)[C@@]2([H])C[C@@H]1NC([C@@H](C3CCCC3)O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 391.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tanaka Y, Nakayama K, Shigenobu K. Inhibitory actions of ONO-3708 on the stretch-induced contraction potentiated by hemolysate/oxyhemoglobin studied in dog cerebral artery. Res Commun Mol Pathol Pharmacol. 1997 Dec;98(3):303-11. PubMed PMID: 9485524.
2: Li BY, Qiao GF, Sun JP, Gao YR, Li WH. Inhibitory effects of ONO-3708 and S-145 on shape change and aggregation of rabbit platelets induced by STA2. Zhongguo Yao Li Xue Bao. 1996 Jul;17(4):345-8. PubMed PMID: 9812720.
3: Haba Y, Kuroda T. Thromboxane A2 receptor antagonist (ONO 3708) protects from liver damage induced by cholestasis and ischemia-reperfusion. Eur Surg Res. 1995;27(2):100-10. PubMed PMID: 7781641.
4: Hanazaki K, Kuroda T, Haba Y, Shiohara E, Kajikawa S, Iida F. Protective effect of the thromboxane A2 receptor antagonist ONO 3708 on ischemia-reperfusion injury in the dog liver. Surgery. 1994 Nov;116(5):896-903. PubMed PMID: 7940195.
5: Kuroda T, Shiohara E, Haba Y, Hanazaki K. The effect of a thromboxane A2 receptor antagonist (ONO 3708) on ischemia-reperfusion injury of the dog pancreas. Transplantation. 1994 Jan;57(2):187-94. PubMed PMID: 7508645.
6: Nagai H, Kumimoto M, Yoshitake K, Iwama T, Arimura A, Koda A. The effect of three novel thromboxane A2 receptor antagonists (S-1452, AA-2414 and ONO-3708) on the increase in pulmonary pressure caused by Forssman anaphylaxis in guinea-pigs. Prostaglandins Leukot Essent Fatty Acids. 1992 Mar;45(3):233-8. PubMed PMID: 1534171.
7: Hanazaki K. [Assessment for protective effects of CoQ10, PGE1 and TXA2 receptor antagonist (ONO-3708) on warm ischemic liver]. Nihon Geka Gakkai Zasshi. 1992 Mar;93(3):274-87. Japanese. PubMed PMID: 1387460.
8: Nagai H, Tsuji F, Inagaki N, Kitagaki K, Fukutomi O, Koda A, Daikoku M. The effect of ONO-3708, a novel TxA2 receptor antagonist, on U-46619-induced contraction of guinea pig and human tracheal strips in vitro and on bronchoconstriction in guinea pigs in vivo. Prostaglandins. 1991 Apr;41(4):375-82. PubMed PMID: 1831278.
9: Shimazawa T, Nagai H, Koda A, Kasahara M. The effects of thromboxane A2 inhibitors (OKY-046 and ONO-3708) and leukotriene inhibitors (AA-861 and LY-171883) on CCl4-induced chronic liver injury in mice. Prostaglandins Leukot Essent Fatty Acids. 1990 May;40(1):67-71. PubMed PMID: 2119043.
10: Nagai H, Aoki M, Shimazawa T, Yakuo I, Koda A, Kasahara M. Effect of OKY-046 and ONO-3708 on liver injury in mice. Jpn J Pharmacol. 1989 Oct;51(2):191-7. PubMed PMID: 2512404.
11: Kondo K, Seo R, Omawari N, Imawaka H, Wakitani K, Kira H, Okegawa T, Kawasaki A. Effects of ONO-3708, an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, on blood vessels. Eur J Pharmacol. 1989 Sep 13;168(2):193-200. PubMed PMID: 2606148.
12: Sasao J, Taneyama C, Kimura M, Kiyono S. [The effects of ONO 3708, a new thromboxane receptor antagonist, on cardiovascular response during the early phases of endotoxin shock in anesthetized dogs]. Masui. 1989 Sep;38(9):1188-94. Japanese. PubMed PMID: 2810716.
13: Taneyama C, Sasao J, Senna S, Kimura M, Kiyono S, Goto H, Arakawa K. Protective effects of ONO 3708, a new thromboxane A2 receptor antagonist, during experimental endotoxin shock. Circ Shock. 1989 May;28(1):69-77. PubMed PMID: 2525079.
14: Kondo K, Seo R, Naka M, Kitagawa T, Wakitani K, Sakata M, Kira H, Okegawa T, Kawasaki A. Effects of ONO-3708, an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, on platelet aggregation and thrombosis. Eur J Pharmacol. 1989 Apr 25;163(2-3):253-61. PubMed PMID: 2721574.
15: Torii T, Toki Y, Hieda N, Ito Y, Okumura K, Hashimoto H, Ito T, Ogawa K, Satake T. Effects of a new thromboxane A2-antagonist (ONO-3708) and a new leukotriene-antagonist (ONO-1078) on thromboxane A2 analogue-, leukotriene C4-, and D4-induced regional myocardial blood flow reduction. Heart Vessels. 1988;4(2):104-11. PubMed PMID: 3253270.
16: Suga H, Hamanaka N, Kondo K, Miyake H, Ohuchida S, Arai Y, Kawasaki A. ONO-3708: an effective thromboxane A2 antagonist possessing 3-acylaminopinane skeleton. Adv Prostaglandin Thromboxane Leukot Res. 1987;17B:799-802. PubMed PMID: 2960194.
17: Kondo K, Seo R, Kitagawa T, Omawari N, Kira H, Okegawa T, Kawasaki A. Preventive effect of ONO-3708 on thrombosis and vasospasms in vitro and in vivo. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:423-6. PubMed PMID: 2959089.
18: Ito T, Ito Y, Torii T, Hieda N, Toki Y, Miyazaki Y, Hashimoto H, Ogawa K, Satake T. Protective effects of selective inhibitor of thromboxane synthetase (OKY-046) and thromboxane antagonist (ONO-3708) on ischemia-induced mitochondrial dysfunction in canine heart. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:392-6. PubMed PMID: 2959085.
19: Fujioka M, Nagao T, Kuriyama H. Actions of the novel thromboxane A2 antagonists, ONO-1270 and ONO-3708, on smooth muscle cells of the guinea-pig basilar artery. Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):468-74. PubMed PMID: 3821937.
20: Kattelman EJ, Venton DL, Le Breton GC. Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548). Thromb Res. 1986 Feb 15;41(4):471-81. PubMed PMID: 3008368.