Hydroxyzine free base
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MedKoo CAT#: 593005

CAS#: 68-88-2 (free base)

Description: Hydroxyzine is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

Chemical Structure

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Hydroxyzine free base
CAS# 68-88-2 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 593005
Name: Hydroxyzine free base
CAS#: 68-88-2 (free base)
Chemical Formula: C21H27ClN2O2
Exact Mass: 374.18
Molecular Weight: 374.910
Elemental Analysis: C, 67.28; H, 7.26; Cl, 9.46; N, 7.47; O, 8.53

Price and Availability

Size Price Availability Quantity
100mg USD 300 2 Weeks
250mg USD 550 2 Weeks
500g USD 950 2 Weeks
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Related CAS #: 68-88-2 (free base)   2192-20-3 (2HCl)   1244-76-4 (HCl)   10246-75-0 (pamoate)   5978-92-7 (pamoate ester)    

Synonym: Hydroxyzine; NSC 169188; NSC-169188; NSC169188; U.C.B 4492;

IUPAC/Chemical Name: Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-

InChi Key: ZQDWXGKKHFNSQK-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2

SMILES Code: ClC1=CC=C(C(N2CCN(CCOCCO)CC2)C3=CC=CC=C3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2933.59.9500

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 374.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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