Hydroxyzine Dihydrochloride
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MedKoo CAT#: 318000

CAS#: 2192-20-3 (2HCl)

Description: Hydroxyzine dihydrochloride is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.


Chemical Structure

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Hydroxyzine Dihydrochloride
CAS# 2192-20-3 (2HCl)

Theoretical Analysis

MedKoo Cat#: 318000
Name: Hydroxyzine Dihydrochloride
CAS#: 2192-20-3 (2HCl)
Chemical Formula: C21H29Cl3N2O2
Exact Mass: 0.00
Molecular Weight: 447.830
Elemental Analysis: C, 56.32; H, 6.53; Cl, 23.75; N, 6.26; O, 7.15

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
5g USD 550 2 Weeks
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Related CAS #: 68-88-2 (free base)   2192-20-3 (2HCl)   1244-76-4 (HCl)   10246-75-0 (pamoate)   5978-92-7 (pamoate ester)    

Synonym: Hydroxyzine dihydrochloride; Hydroxyzine hydrochloride; Arcanax; Neurolax; Orgatrax; Pamoate, Hydroxyzine; Vistaril; NSC 169188; NSC-169188; NSC169188; U.C.B 4492;

IUPAC/Chemical Name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride

InChi Key: ANOMHKZSQFYSBR-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

SMILES Code: ClC1=CC=C(C(N2CCN(CCOCCO)CC2)C3=CC=CC=C3)C=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 447.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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