CGP-71683A HCl
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524661

CAS#: 192322-50-2 (HCl)

Description: CGP 71683A is a potent and highly selective non-peptide antagonist of the NPY Y(5) receptor in the study of obesity.

Chemical Structure

img
CGP-71683A HCl
CAS# 192322-50-2 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 524661
Name: CGP-71683A HCl
CAS#: 192322-50-2 (HCl)
Chemical Formula: C26H30ClN5O2S
Exact Mass: 0.00
Molecular Weight: 512.070
Elemental Analysis: C, 60.98; H, 5.91; Cl, 6.92; N, 13.68; O, 6.25; S, 6.26

Price and Availability

Size Price Availability Quantity
50mg USD 450
100mg USD 750
200mg USD 1250
500mg USD 1950
1g USD 2950
2g USD 5450
Bulk inquiry

Related CAS #: 192321-23-6 (free base)   192322-50-2 (HCl)    

Synonym: CGP-71683A; CGP 71683A; CGP71683A; CGP-71683A HCl

IUPAC/Chemical Name: N-(((1r,4r)-4-(((4-aminoquinazolin-2-yl)amino)methyl)cyclohexyl)methyl)naphthalene-1-sulfonamide hydrochloride

InChi Key: DIQDKUNCSVFGHH-VPLSKCCHSA-N

InChi Code: InChI=1S/C26H29N5O2S.ClH/c27-25-22-9-3-4-10-23(22)30-26(31-25)28-16-18-12-14-19(15-13-18)17-29-34(32,33)24-11-5-7-20-6-1-2-8-21(20)24;/h1-11,18-19,29H,12-17H2,(H3,27,28,30,31);1H/t18-,19-;

SMILES Code: O=S(C1=C2C=CC=CC2=CC=C1)(NC[C@H]3CC[C@H](CNC4=NC(N)=C5C=CC=CC5=N4)CC3)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 512.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ghahramanian Golzar M, Babri S, Ataie Z, Ebrahimi H, Mirzaie F, Mohaddes G. NPY Receptors Blockade Prevents Anticonvulsant Action of Ghrelin in the Hippocampus of Rat. Adv Pharm Bull. 2013;3(2):265-71. doi: 10.5681/apb.2013.043. Epub 2013 Aug 20. PubMed PMID: 24312846; PubMed Central PMCID: PMC3848244.

2: Li L, Mayer M, Schneider E, Schreiber E, Bernhardt G, Peng S, Buschauer A. Preparation of fluorescent nonpeptidic neuropeptide Y receptor ligands: analogues of the quinazoline-type anti-obesity Y5 antagonist CGP 71683A. Arch Pharm (Weinheim). 2003 Dec;336(12):585-90. PubMed PMID: 14677152.

3: Lecklin A, Lundell I, Paananen L, Wikberg JE, Männistö PT, Larhammar D. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135(8):2029-37. PubMed PMID: 11959807; PubMed Central PMCID: PMC1573328.

4: Della Zuana O, Sadlo M, Germain M, Félétou M, Chamorro S, Tisserand F, de Montrion C, Boivin JF, Duhault J, Boutin JA, Levens N. Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade. Int J Obes Relat Metab Disord. 2001 Jan;25(1):84-94. PubMed PMID: 11244462.

5: Mullins DE, Guzzi M, Xia L, Parker EM. Pharmacological characterization of the cloned neuropeptide Y y(6) receptor. Eur J Pharmacol. 2000 Apr 28;395(2):87-93. PubMed PMID: 10794812.

6: Parker EM, Balasubramaniam A, Guzzi M, Mullins DE, Salisbury BG, Sheriff S, Witten MB, Hwa JJ. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9. PubMed PMID: 10793222.

7: Polidori C, Ciccocioppo R, Regoli D, Massi M. Neuropeptide Y receptor(s) mediating feeding in the rat: characterization with antagonists. Peptides. 2000 Jan;21(1):29-35. PubMed PMID: 10704716.

8: Félétou M, Nicolas JP, Rodriguez M, Beauverger P, Galizzi JP, Boutin JA, Duhault J. NPY receptor subtype in the rabbit isolated ileum. Br J Pharmacol. 1999 Jun;127(3):795-801. PubMed PMID: 10401572; PubMed Central PMCID: PMC1566062.

9: Criscione L, Rigollier P, Batzl-Hartmann C, Rüeger H, Stricker-Krongrad A, Wyss P, Brunner L, Whitebread S, Yamaguchi Y, Gerald C, Heurich RO, Walker MW, Chiesi M, Schilling W, Hofbauer KG, Levens N. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J Clin Invest. 1998 Dec 15;102(12):2136-45. PubMed PMID: 9854049; PubMed Central PMCID: PMC509168.