CGP-54626 HCl
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MedKoo CAT#: 524644

CAS#: 149184-21-4 (HCl)

Description: CGP-54626 is a selective antagonist of the GABAB receptor with an IC50 value of 4 nM.1 It can be used to investigate the role of GABAB receptors in neurological signaling.

Chemical Structure

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CGP-54626 HCl
CAS# 149184-21-4 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 524644
Name: CGP-54626 HCl
CAS#: 149184-21-4 (HCl)
Chemical Formula: C18H29Cl3NO3P
Exact Mass: 0.00
Molecular Weight: 444.760
Elemental Analysis: C, 48.61; H, 6.57; Cl, 23.91; N, 3.15; O, 10.79; P, 6.96

Price and Availability

Size Price Availability Quantity
5mg USD 265
10mg USD 425
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Related CAS #: 149184-21-4 (HCl)   149936-58-3 (free base)    

Synonym: CGP 54626A Hydrochloride; CGP 54626A HCl; CGP 54626A; CGP-54626A; CGP54626A.

IUPAC/Chemical Name: (S)-(cyclohexylmethyl)((S)-3-(((S)-1-(3,4-dichlorophenyl)ethyl)amino)-2-hydroxypropyl)phosphinic acid hydrochloride

InChi Key: ZQCFHOVIXCJPLE-LINSIKMZSA-N

InChi Code: InChI=1S/C18H28Cl2NO3P.ClH/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14;/h7-9,13-14,16,21-22H,2-6,10-12H2,1H3,(H,23,24);1H/t13-,16-;/m0./s1

SMILES Code: O=[P@@](O)(C[C@H](CN[C@@H](C)c1cc(c(cc1)Cl)Cl)O)CC1CCCCC1.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 444.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, Bettler B, Taylor V. GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development. 2014 Jan;141(1):83-90. doi: 10.1242/dev.102608. Epub 2013 Nov 27. PubMed PMID: 24284211.

2: Wang T, Rusu SI, Hruskova B, Turecek R, Borst JG. Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity. J Physiol. 2013 Oct 1;591(19):4877-94. doi: 10.1113/jphysiol.2013.256875. Epub 2013 Aug 12. PubMed PMID: 23940376; PubMed Central PMCID: PMC3800460.

3: Samengo IA, Scotti V, Martire M. Co-application of the GABAB receptor agonist, baclofen, and the mGlu receptor agonist, L-CCG-I, facilitates [(3)H]GABA release from rat cortical nerve endings. J Neural Transm (Vienna). 2013 Dec;120(12):1641-9. doi: 10.1007/s00702-013-1057-2. Epub 2013 Jul 3. PubMed PMID: 23821368.

4: Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M. Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat Neurosci. 2013 Aug;16(8):1068-76. doi: 10.1038/nn.3446. Epub 2013 Jun 30. PubMed PMID: 23817549; PubMed Central PMCID: PMC3729586.

5: Padgett CL, Lalive AL, Tan KR, Terunuma M, Munoz MB, Pangalos MN, Martínez-Hernández J, Watanabe M, Moss SJ, Luján R, Lüscher C, Slesinger PA. Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Neuron. 2012 Mar 8;73(5):978-89. doi: 10.1016/j.neuron.2011.12.031. PubMed PMID: 22405207; PubMed Central PMCID: PMC3560416.

6: Wu Y, Wang HY, Lin CC, Lu HC, Cheng SJ, Chen CC, Yang HW, Min MY. GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat. J Neurophysiol. 2011 Jun;105(6):2715-28. doi: 10.1152/jn.00459.2010. Epub 2011 Mar 23. PubMed PMID: 21430282.