Centanafadine HCl
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MedKoo CAT#: 319540

CAS#: 923981-14-0 (HCl)

Description: Centanafadine, also known as EB-1020, is an adrenergic uptake inhibitor and dopamine uptake inhibitor and serotonin uptake inhibitor. Centanafadine modulates norepinephrine, dopamine and, to a lesser extent, serotonin reuptake in a ratio of 1:6:14, respectively to improve focus, attention and executive function.

Chemical Structure

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Centanafadine HCl
CAS# 923981-14-0 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 319540
Name: Centanafadine HCl
CAS#: 923981-14-0 (HCl)
Chemical Formula: C15H16ClN
Exact Mass: 0.00
Molecular Weight: 245.750
Elemental Analysis: C, 73.31; H, 6.56; Cl, 14.43; N, 5.70

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10mg USD 300
50mg USD 990
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Related CAS #: 924012-43-1 (free base)   923981-14-0 (HCl)    

Synonym: EB-1020; EB 1020; EB1020; EB-1020 SR; CTN SR; Centanafadine

IUPAC/Chemical Name: (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochoride

InChi Key: ACVMJAJGCQUPKX-LIOBNPLQSA-N

InChi Code: InChI=1S/C15H15N.ClH/c1-2-4-12-7-13(6-5-11(12)3-1)15-8-14(15)9-16-10-15;/h1-7,14,16H,8-10H2;1H/t14-,15+;/m1./s1

SMILES Code: [H][C@@]12CNC[C@]1(C3=CC=C4C=CC=CC4=C3)C2.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 245.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bymaster FP, Golembiowska K, Kowalska M, Choi YK, Tarazi FI. Pharmacological
characterization of the norepinephrine and dopamine reuptake inhibitor EB-1020:
implications for treatment of attention-deficit hyperactivity disorder. Synapse.
2012 Jun;66(6):522-32. doi: 10.1002/syn.21538. Epub 2012 Feb 22. PubMed PMID:
22298359.