RP-6685 HCl

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MedKoo CAT#: 126357

CAS#: RP-6685 HCl

Description: RP-6685 is a potent, selective, and orally bioavailable Polθ inhibitor that showed in vivo efficacy in an HCT116 BRCA2−/− mouse tumor xenograft model. RP-6685 was extremely potent with an IC50 of 550 pM against the pol activity of full-length Polθ and inactive on the ATPase activity. RP-6685 displayed a favorable PK profile with good oral bioavailability in mouse.

Chemical Structure

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RP-6685 HCl
CAS# RP-6685 HCl
Instruction

Theoretical Analysis

MedKoo Cat#: 126357
Name: RP-6685 HCl
CAS#: RP-6685 HCl
Chemical Formula: C22H16Cl2F7N5O
Exact Mass: 497.11
Molecular Weight: 570.293
Elemental Analysis: C, 46.33; H, 2.83; Cl, 12.43; F, 23.32; N, 12.28; O, 2.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: RP-6685 HCl   2832047-80-8 (free base)    

Synonym: RP-6685 HCl; RP-6685 dihychloride, RP-6685; RP 6685; RP6685;

IUPAC/Chemical Name: N-(3-(6-aminopyridazin-3-yl)prop-2-yn-1-yl)-2-(3,5-bis(trifluoromethyl)pyridin-2-yl)-N-(4-fluorophenyl)acetamide dihydrochloride

InChi Key: SRUWNAQPOYQICD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H14F7N5O.2ClH/c23-14-3-6-16(7-4-14)34(9-1-2-15-5-8-19(30)33-32-15)20(35)11-18-17(22(27,28)29)10-13(12-31-18)21(24,25)26;;/h3-8,10,12H,9,11H2,(H2,30,33);2*1H

SMILES Code: O=C(N(CC#CC1=NN=C(N)C=C1)C2=CC=C(F)C=C2)CC3=NC=C(C(F)(F)F)C=C3C(F)(F)F.[H]Cl.[H]Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 570.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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