Ropitoin HCl

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MedKoo CAT#: 126158

CAS#: 56079-80-2 (HCl)

Description: Ropitoin (TR2985) is a diphenylhydantoin derivative.

Chemical Structure

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Ropitoin HCl
CAS# 56079-80-2 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 126158
Name: Ropitoin HCl
CAS#: 56079-80-2 (HCl)
Chemical Formula: C30H34ClN3O3
Exact Mass: 519.23
Molecular Weight: 520.070
Elemental Analysis: C, 69.28; H, 6.59; Cl, 6.82; N, 8.08; O, 9.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 56079-80-2 (HCl)   56079-81-3 (free base)  

Synonym: Ropitoin; TR2985; ROPITOIN HYDROCHLORIDE; Ropitoin HCl; Ropitoin hydrochloride

IUPAC/Chemical Name: 5-(4-methoxyphenyl)-5-phenyl-3-(3-(4-phenylpiperidin-1-yl)propyl)imidazolidine-2,4-dione hydrochloride

InChi Key: IYHQTOOPUMZKRX-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H33N3O3.ClH/c1-36-27-15-13-26(14-16-27)30(25-11-6-3-7-12-25)28(34)33(29(35)31-30)20-8-19-32-21-17-24(18-22-32)23-9-4-2-5-10-23;/h2-7,9-16,24H,8,17-22H2,1H3,(H,31,35);1H

SMILES Code: Cl.COC1=CC=C(C=C1)C2(NC(=O)N(CCCN3CCC(CC3)C4=CC=CC=C4)C2=O)C5=CC=CC=C5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 520.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Elizalde A, Sanchéz-Chapula J. Effects of the novel antiarrhythmic compound TR 2985 (ropitoin) on action potentials of different mammalian cardiac tissues. Naunyn Schmiedebergs Arch Pharmacol. 1988 Mar;337(3):316-22. PubMed PMID: 3393234.

2: Valenzuela C, Sanchez-Chapula J. Electrophysiologic interactions between mexiletine-quinidine and mexiletine-ropitoin in guinea pig papillary muscle. J Cardiovasc Pharmacol. 1989 Nov;14(5):783-9. PubMed PMID: 2481194.

3: Hong E, Gonzalez-Jasso E, Peon J. Antiarrhythmic activity of ropitoin in rats subjected to coronary artery ligation. Proc West Pharmacol Soc. 1986;29:15-7. PubMed PMID: 3763601.