Tigloidine hydrobromide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 126093

CAS#: 22846-83-9 (HBr)

Description: Tigloidine is a tropane alkaloid and a naturally occurring analog of atropine, found in small quantities in Duboisia myoporoides. Tigloidine has been found to be beneficial in the treatment of Parkinsonism, Huntington’s Chorea and spastic paraplegia.

Chemical Structure

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Tigloidine hydrobromide
CAS# 22846-83-9 (HBr)
Instruction

Theoretical Analysis

MedKoo Cat#: 126093
Name: Tigloidine hydrobromide
CAS#: 22846-83-9 (HBr)
Chemical Formula: C13H22BrNO2
Exact Mass: 303.08
Molecular Weight: 304.228
Elemental Analysis: C, 51.32; H, 7.29; Br, 26.26; N, 4.60; O, 10.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Related CAS #: 495-83-0 (free base)   22846-83-9 (HBr)  

Synonym: Tigloidine hydrobromide; Tigloidine HBr; Tropigline; tigloidin; Tigloidine; Tiglylpseudotropine;

IUPAC/Chemical Name: 8-methyl-8-azabicyclo[3.2.1]octan-3-yl (E)-2-methylbut-2-enoate hydrobromide

InChi Key: DSEWSAPMBJUWNX-JOKMOOFLSA-N

InChi Code: InChI=1S/C13H21NO2.BrH/c1-4-9(2)13(15)16-12-7-10-5-6-11(8-12)14(10)3;/h4,10-12H,5-8H2,1-3H3;1H/b9-4+;

SMILES Code: C/C=C(C(OC1CC2CCC(N2C)C1)=O)\C.Br

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 304.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: TRAUTNER EM, NOACK CH. Tigloidine as a substitute for atropine in the
treatment of Parkinsonism. Med J Aust. 1951 May 26;1(21):751-4. doi:
10.5694/j.1326-5377.1951.tb56491.x. PMID: 14852182.

2: O'ROURKE FJ, GERSHON S, TRAUTNER EM, SHAW FH. The use of tigloidine in the
symptomatic treatment of spastic paraplegia. Med J Aust. 1960 Jan 16;47(1):73-7.
doi: 10.5694/j.1326-5377.1960.tb86940.x. PMID: 14428122.

3: Sanghvi I, Bindler E, Gershon S. Pharmacology of a potential anti-Parkinson
agent: tigloidine. Eur J Pharmacol. 1968 Oct;4(3):246-53. doi:
10.1016/0014-2999(68)90091-5. PMID: 5723419.

4: TRAUTNER EM, GERSHON S. The effect of tigloidine on extrapyramidal syndromes
(Huntington's chorea). Australas Ann Med. 1958 Nov;7(4):286-91. doi:
10.1111/imj.1958.7.4.286. PMID: 13607328.