Tetroquinone disodium

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MedKoo CAT#: 125987

CAS#: 1887-02-1 (disodium)

Description: Tetroquinone (Tetrahydroxy-1,4-benzoquinone, tetrahydroxy-p-benzoquinone, tetrahydroxybenzoquinone) is cyclohexadiene derivative with four hydroxyl groups and two ketone groups in opposite (para) positions, with potent prooxidant activity.

Chemical Structure

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Tetroquinone disodium
CAS# 1887-02-1 (disodium)
Instruction

Theoretical Analysis

MedKoo Cat#: 125987
Name: Tetroquinone disodium
CAS#: 1887-02-1 (disodium)
Chemical Formula: C6H2Na2O6
Exact Mass: 215.96
Molecular Weight: 216.056
Elemental Analysis: C, 33.36; H, 0.93; Na, 21.28; O, 44.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 319-89-1 (free base)   1887-02-1 (disodium)   5676-48-2 (dihydrate)  

Synonym: Tetroquinone disodium; Tetroquinone; Tetrahydroxy-1,4-benzoquinone; tetrahydroxy-p-benzoquinone; tetrahydroxybenzoquinone;

IUPAC/Chemical Name: sodium 4,6-dihydroxy-2,5-dioxocyclohexa-3,6-diene-1,3-bis(olate)

InChi Key: SOSMJTGSYNGZAV-UHFFFAOYSA-L

InChi Code: InChI=1S/C6H4O6.2Na/c7-1-2(8)4(10)6(12)5(11)3(1)9;;/h7-8,11-12H;;/q;2*+1/p-2

SMILES Code: [Na+].[Na+].OC1=C([O-])C(=O)C([O-])=C(O)C1=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 216.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Majidi L, Ahmadiparidari A, Shan N, Misal SN, Kumar K, Huang Z, Rastegar S, Hemmat Z, Zou X, Zapol P, Cabana J, Curtiss LA, Salehi-Khojin A. 2D Copper Tetrahydroxyquinone Conductive Metal-Organic Framework for Selective CO2 Electrocatalysis at Low Overpotentials. Adv Mater. 2021 Feb 1:e2004393. doi: 10.1002/adma.202004393. Epub ahead of print. PMID: 33522009.

2: Chen G, Gee LB, Xu W, Zhu Y, Lezama-Pacheco JS, Huang Z, Li Z, Babicz JT Jr, Choudhury S, Chang TH, Reed E, Solomon EI, Bao Z. Valence-Dependent Electrical Conductivity in a 3D Tetrahydroxyquinone-Based Metal-Organic Framework. J Am Chem Soc. 2020 Dec 23;142(51):21243-21248. doi: 10.1021/jacs.0c09379. Epub 2020 Dec 14. PMID: 33315385.

3: Park J, Hinckley AC, Huang Z, Feng D, Yakovenko AA, Lee M, Chen S, Zou X, Bao Z. Synthetic Routes for a 2D Semiconductive Copper Hexahydroxybenzene Metal- Organic Framework. J Am Chem Soc. 2018 Nov 7;140(44):14533-14537. doi: 10.1021/jacs.8b06666. Epub 2018 Oct 30. PMID: 30176142.

4: Lo Cicero M, Della Pia A, Riello M, Colazzo L, Sedona F, Betti MG, Sambi M, De Vita A, Mariani C. A long-range ordered array of copper tetrameric units embedded in an on-surface metal organic framework. J Chem Phys. 2017 Dec 7;147(21):214706. doi: 10.1063/1.5004082. PMID: 29221400.

5: Fouad DM, Ismail NM, El-Gahami MA, Ibrahim SA. Kinetics of the substitution of dehydroacetic acid in tris (dehydroacetato) Fe(III) complex by 8-hydroxyquinoline, di- and tetra-hydroxyquinone. Spectrochim Acta A Mol Biomol Spectrosc. 2007 Jun;67(2):564-7. doi: 10.1016/j.saa.2006.05.039. Epub 2006 Aug 18. PMID: 17049303.

6: Martins Cavagis AD, Ferreira CV, Versteeg HH, Assis CF, Bos CL, Bleuming SA, Diks SH, Aoyama H, Peppelenbosch MP. Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signaling. Exp Hematol. 2006 Feb;34(2):188-96. doi: 10.1016/j.exphem.2005.11.001. PMID: 16459187.

7: Ching R. Tetrahydroxyquinone (THQ): its use in ophthalmology. Eye Ear Nose Throat Mon. 1971 Apr;50(4):144-9. PMID: 5572985.

8: Ching R. Tetrahydroxyquinone (THQ) its use in ophthalmology. I. Eye Ear Nose Throat Mon. 1971 Mar;50(3):101-7 contd. PMID: 5552869.

9: Takeuchi S, Inoue Y. Hypoglycemic actions of tetrahydroxyquinone, rhodizonic acid and trichinoyl in mice and rabbits. Jpn J Pharmacol. 1968 Sep;18(3):312-20. doi: 10.1254/jjp.18.312. PMID: 5304400.

10: Satoh GJ, Kelly EW Jr. Changes in the collagen and acid mucopolysaccharides of rat skin during the calciphylactic calciferol-albumin syndrome and the effect of simultaneous administration of tetrahydroxyquinone. J Invest Dermatol. 1967 Jan;48(1):1-6. doi: 10.1038/jid.1967.1. PMID: 4225134.

11: Keech MK, McCann DS, Boyle AJ, Pinkus H. Effect of ethylenediaminetetraacetic acid (EDTA) and tetrahydroxyquinone on sclerodermatous skin. Histologic and chemical studies. J Invest Dermatol. 1966 Sep;47(3):235-46. doi: 10.1038/jid.1966.136. PMID: 4958819.

12: KELLY EW Jr. TETRAHYDROXYQUINONE (THQ) EFFECTS ON SPONGE IMPLANTS IN THE ALBINO RAT. Arch Pathol. 1964 Mar;77:317-23. PMID: 14095749.

13: KELLY EW Jr. The effects of tetrahydroxyquinone on connective tissue. J Chronic Dis. 1963 Apr;16:335-42. doi: 10.1016/0021-9681(63)90084-5. PMID: 14031813.

14: SERIS JL, BRU A. [The protective effect of tetrahydroxyquinone against the action of x-rays on baker's yeasts]. C R Hebd Seances Acad Sci. 1962 Jul 23;255:791-3. French. PMID: 13910826.

15: PREISLER PW, BERGER L, HILL ES. Oxidation-reduction potentials and ionization constants of the reversible series; hexahydroxybenzene- tetrahydroxyquinone-rhodizonic acid. J Am Chem Soc. 1948 Feb;70(2):871. doi: 10.1021/ja01182a515. PMID: 18933297.