Mannose 6 phosphate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125947

CAS#: 3672-15-9 (free base)

Description: Mannose 6-phosphate (M6P) has type-I integral membrane receptors.

Chemical Structure

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Mannose 6 phosphate
CAS# 3672-15-9 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 125947
Name: Mannose 6 phosphate
CAS#: 3672-15-9 (free base)
Chemical Formula: C6H13O9P
Exact Mass: 260.03
Molecular Weight: 260.135
Elemental Analysis: C, 27.70; H, 5.04; O, 55.35; P, 11.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 3672-15-9 (free base)   70442-25-0 (sodium)  

Synonym: Mannose 6 phosphate; Mannose 6-phosphate; Mannose-6-phosphate; D-mannose 6-phosphate; D-Mannose, 6-(dihydrogen phosphate), monosodium

IUPAC/Chemical Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexyl dihydrogen phosphate

InChi Key: VFRROHXSMXFLSN-KVTDHHQDSA-N

InChi Code: InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h1,3-6,8-11H,2H2,(H2,12,13,14)/t3-,4-,5-,6-/m1/s1

SMILES Code: O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H](O)C=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 260.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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role in lysosomal function and dysfunction. Mol Genet Metab. 2012
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22266136.

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L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M. GCAF(TMEM251) regulates
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PMC9468337.

3: Meunier M, Chapuis E, Lapierre L, Auriol P, Paulus C, Elbaum B, Don Simoni E,
Sandré J, Auriol D, Scandolera A, Reynaud R. Mannose-6-phosphate complex and
improvement in biomechanical properties of the skin. J Cosmet Dermatol. 2021
Jun;20(6):1598-1610. doi: 10.1111/jocd.14000. Epub 2021 Mar 10. PMID: 33580613;
PMCID: PMC8251629.

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10.1080/15548627.2023.2167376. Epub 2023 Jan 22. PMID: 36633450; PMCID:
PMC10283412.

5: Dalle Vedove E, Costabile G, Merkel OM. Mannose and Mannose-6-Phosphate
Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy.
Adv Healthc Mater. 2018 Jul;7(14):e1701398. doi: 10.1002/adhm.201701398. Epub
2018 May 2. PMID: 29719138; PMCID: PMC6108418.

6: Castonguay AC, Olson LJ, Dahms NM. Mannose 6-phosphate receptor homology
(MRH) domain-containing lectins in the secretory pathway. Biochim Biophys Acta.
2011 Sep;1810(9):815-26. doi: 10.1016/j.bbagen.2011.06.016. Epub 2011 Jun 24.
PMID: 21723917; PMCID: PMC3150748.

7: Zhang B, Yang X, Li M. LYSET/TMEM251/GCAF is critical for autophagy and
lysosomal function by regulating the mannose-6-phosphate (M6P) pathway.
Autophagy. 2023 May;19(5):1596-1598. doi: 10.1080/15548627.2023.2167375. Epub
2023 Jan 16. PMID: 36633445; PMCID: PMC10240974.

8: Sletten ET, Danglad-Flores J, Leichnitz S, Abragam Joseph A, Seeberger PH.
Expedited synthesis of mannose-6-phosphate containing oligosaccharides.
Carbohydr Res. 2022 Jan;511:108489. doi: 10.1016/j.carres.2021.108489. Epub 2021
Dec 11. PMID: 34922155.

9: Gorelik A, Illes K, Bui KH, Nagar B. Structures of the mannose-6-phosphate
pathway enzyme, GlcNAc-1-phosphotransferase. Proc Natl Acad Sci U S A. 2022 Aug
16;119(33):e2203518119. doi: 10.1073/pnas.2203518119. Epub 2022 Aug 8. PMID:
35939698; PMCID: PMC9388126.