Parbendazole monohydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125595

CAS#: 83601-81-4 (HCl)

Description: Parbendazole is a potent inhibitor of microtubule assembly that was studied as an anthelmintic agent.

Chemical Structure

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Parbendazole monohydrochloride
CAS# 83601-81-4 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 125595
Name: Parbendazole monohydrochloride
CAS#: 83601-81-4 (HCl)
Chemical Formula: C13H18ClN3O2
Exact Mass: 283.11
Molecular Weight: 283.760
Elemental Analysis: C, 55.03; H, 6.39; Cl, 12.49; N, 14.81; O, 11.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 14255-87-9 (free base)   83601-81-4 (HCl)  

Synonym: Parbendazole monohydrochloride; Parabendazole monohydrochloride; UNII-YV5RTO20GO; YV5RTO20GO; 83601-81-4

IUPAC/Chemical Name: methyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate hydrochloride

InChi Key: KQIVUXJJSRFRFM-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H17N3O2.ClH/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2;/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17);1H

SMILES Code: Cl.CCCCC1=CC2=C(NC(NC(=O)OC)=N2)C=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 283.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Brum AM, van de Peppel J, van der Leije CS, Schreuders-Koedam M, Eijken M, van der Eerden BC, van Leeuwen JP. Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12711-6. doi: 10.1073/pnas.1501597112. Epub 2015 Sep 29. PubMed PMID: 26420877; PubMed Central PMCID: PMC4611615.

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6: Hennessy DR, Steel JW, Dash KM, Lisle KA, Pearson IG. Potentiation by parbendazole of the anthelmintic activity of oxfendazole against natural infections of benzimidazole resistant nematodes. Aust Vet J. 1987 Jan;64(1):28-9. PubMed PMID: 3593136.

7: Wildgoose CL, Steele CE. In vitro teratogenicity of parbendazole. Arch Toxicol Suppl. 1987;11:172-4. PubMed PMID: 3477162.

8: Hennessy DR, Lacey E, Prichard RK, Steel JW. Potentiation of the anthelmintic activity of oxfendazole by parbendazole. J Vet Pharmacol Ther. 1985 Sep;8(3):270-5. PubMed PMID: 3840535.

9: Prozesky L, Joubert JP, Ekron MD. Paralysis in lambs caused by overdosing with parbendazole. Onderstepoort J Vet Res. 1981 Sep;48(3):159-67. PubMed PMID: 6895936.

10: Havercroft JC, Quinlan RA, Gull K. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204. PubMed PMID: 7031071.

11: Pereverzeva EV, Veretennikova NL, Ozeretskovskaia NN. [The effect of fenbendazole and parbendazole on the course of experimental trichinelliasis in white mice]. Med Parazitol (Mosk). 1981 Mar-Apr;50(2):46-50. Russian. PubMed PMID: 6894480.

12: Quinlan RA, Roobol A, Pogson CI, Gull K. A correlation between in vivo and in vitro effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on myxamoebae of Physarum polycephalum. J Gen Microbiol. 1981 Jan;122(1):1-6. PubMed PMID: 6895648.

13: Cruthers LR, James TM, Goff S. Efficacy of a tribromosalan and parbendazole composition against adult Fasciola hepatica in sheep. Res Vet Sci. 1981 Jan;30(1):122-3. PubMed PMID: 6894647.

14: Lyons ET, Drudge JH, Tolliver SC. Antiparasitic activity of parbendazole in critical tests in horses. Am J Vet Res. 1980 Jan;41(1):123-4. PubMed PMID: 6892671.

15: Varshney TR, Singh YP. A comparative sutdy of anthelmintic effect of naphthalophos and parbendazole against natural infection of gastro-intestinal worms of sheep. Indian Vet J. 1979 Mar;56(3):207-10. PubMed PMID: 582588.

16: Mercier-Parot L. [The teratogenic action of parbendazole]. Therapie. 1976 Jul-Aug;31(4):491-503. French. PubMed PMID: 1036798.

17: Delatour P, Lorgue G, Lapras M, Richard Y. [Embryotoxic and antimitotic properties of parbendazole, mebendazole and cambendazole]. C R Acad Sci Hebd Seances Acad Sci D. 1976 Feb 2;282(5):517-8. French. PubMed PMID: 817814.

18: Verberne LR, Mirck MH. [Concerning the toxicity of parbendazole (Helmatac 30) to horses and ponies (author's transl)]. Tijdschr Diergeneeskd. 1975 Nov 1;100(21):1143-52. Dutch. PubMed PMID: 1242825.

19: DiCuollo CJ, Miller JA, Mendelson WL, Pagano JF. Metabolic and tissue residue studies on parbendazole in sheep. J Agric Food Chem. 1974 Nov-Dec;22(6):948-53. PubMed PMID: 4430805.

20: Borgsteede FH. [Activity of parbendazole against gastro-intestinal nematodes in calves (author's transl)]. Tijdschr Diergeneeskd. 1974 Oct 1;99(19):991-5. Dutch. PubMed PMID: 4408472.