Phenadoxone HCl

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MedKoo CAT#: 125294

CAS#: 20874-24-2 (HCl)

Description: Phenadoxone hydrochloride is one of some forty amino-ketones and amino-esters related to amidone. The compound is a very potent analgesic for the rat; by the subcutaneous route it is more active than either morphine or amidone.

Chemical Structure

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Phenadoxone HCl
CAS# 20874-24-2 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 125294
Name: Phenadoxone HCl
CAS#: 20874-24-2 (HCl)
Chemical Formula: C23H30ClNO2
Exact Mass: 387.20
Molecular Weight: 387.950
Elemental Analysis: C, 71.21; H, 7.79; Cl, 9.14; N, 3.61; O, 8.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 20874-24-2 (HCl)   467-84-5 (free base)  

Synonym: Hepagin; Heptalgin; Supralgin; Phenadoxone hydrochloride; Heptazone hydrochloride

IUPAC/Chemical Name: 6-morpholino-4,4-diphenylheptan-3-one hydrochloride

InChi Key: QGUPBYVADAJUNT-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H29NO2.ClH/c1-3-22(25)23(20-10-6-4-7-11-20,21-12-8-5-9-13-21)18-19(2)24-14-16-26-17-15-24;/h4-13,19H,3,14-18H2,1-2H3;1H

SMILES Code: Cl.CCC(=O)C(CC(C)N1CCOCC1)(C2=CC=CC=C2)C3=CC=CC=C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 387.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: SHAW WH, JEFFERIES JP. The determination of phenadoxone. J Pharm Pharmacol. 1951 Nov;3(11):823-8. doi: 10.1111/j.2042-7158.1951.tb13126.x. PMID: 14898462.

2: BASIL B, EDGE ND, SOMERS GF. The pharmacology of phenadoxone or dl-6-morpholino-4:4-diphenyl-heptan-3-one hydrochloride. Br J Pharmacol Chemother. 1950 Mar;5(1):125-41. doi: 10.1111/j.1476-5381.1950.tb00582.x. PMID: 15405474; PMCID: PMC1509948.

3: VENTURI VM. Farmacologia del fenadoxone [Pharmacology of phenadoxone]. Farmaco Sci Tec. 1950 Mar-Apr;5(2):185-6. Undetermined Language. PMID: 15421358.

4: Robinson K, Smith RN. Methadone radioimmunoassay: two simple methods. J Pharm Pharmacol. 1983 Sep;35(9):566-70. doi: 10.1111/j.2042-7158.1983.tb04334.x. PMID: 6138405.

5: GREEN AF. Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion. Br J Pharmacol Chemother. 1959 Mar;14(1):26-34. doi: 10.1111/j.1476-5381.1959.tb00924.x. PMID: 13651575; PMCID: PMC1481834.

6: Paton WD. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. 1956. Br J Pharmacol. 1997 Feb;120(4 Suppl):123-31; discussion 121-2. doi: 10.1111/j.1476-5381.1997.tb06787.x. PMID: 9142400; PMCID: PMC3224282.

7: PATON WD. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br J Pharmacol Chemother. 1957 Mar;12(1):119-27. doi: 10.1111/j.1476-5381.1957.tb01373.x. PMID: 13413163; PMCID: PMC1509640.