Bevonium methylsulfate

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MedKoo CAT#: 204920

CAS#: 5205-82-3 (methylsulfate)

Description: Bevonium methylsulfate (CG-201), currently being developed by CG Therapeutics, Inc. is an injection that stimulates antibodies to block the pathological forms of hCG that help cancer cells grow and evade the immune system. According to CG Therapeutics's website, CG201 was originally created in collaboration with the World Health Organization as a low-cost contraceptive method for developing countries. CG201 is now approved for a Phase I clinical trial in Sweden. A single injection can protect against pregnancy for up to one year, and protection is reversible after that.

Chemical Structure

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Bevonium methylsulfate
CAS# 5205-82-3 (methylsulfate)
Instruction

Theoretical Analysis

MedKoo Cat#: 204920
Name: Bevonium methylsulfate
CAS#: 5205-82-3 (methylsulfate)
Chemical Formula: C23H31NO7S
Exact Mass: 0.00
Molecular Weight: 465.560
Elemental Analysis: C, 59.34; H, 6.71; N, 3.01; O, 24.06; S, 6.89

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 33371-53-8 (cation)   5205-82-3 (methylsulfate)    

Synonym: CG201; CG 201; CG-201; Bevonium methylsulfate; Acabel; Piribenzil methosulfate; Piribenzil methyl sulfate; Bevonium metilsulfate.

IUPAC/Chemical Name: 2-((2-hydroxy-2,2-diphenylacetoxy)methyl)-1,1-dimethylpiperidin-1-ium methyl sulfate.

InChi Key: AXKJGGRSAVLXTE-UHFFFAOYSA-M

InChi Code: InChI=1S/C22H28NO3.CH4O4S/c1-23(2)16-10-9-15-20(23)17-26-21(24)22(25,18-11-5-3-6-12-18)19-13-7-4-8-14-19;1-5-6(2,3)4/h3-8,11-14,20,25H,9-10,15-17H2,1-2H3;1H3,(H,2,3,4)/q+1;/p-1

SMILES Code: C[N+]1(C)C(COC(C(C2=CC=CC=C2)(O)C3=CC=CC=C3)=O)CCCC1.O=S(OC)([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:          

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 465.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stall L, Lee J, McCullough M, Nsrouli-Maktabi H, Spies JB. Effectiveness of elective unilateral uterine artery embolization: a case-control study. J Vasc Interv Radiol. 2011 May;22(5):716-22. PubMed PMID: 21514525.

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7: White AM, Banovac F, Spies JB. Patient radiation exposure during uterine fibroid embolization and the dose attributable to aortography. J Vasc Interv Radiol. 2007 Apr;18(4):573-6. PubMed PMID: 17446550.

8: Spies JB, Cornell C, Worthington-Kirsch R, Lipman JC, Benenati JF. Long-term outcome from uterine fibroid embolization with tris-acryl gelatin microspheres: results of a multicenter study. J Vasc Interv Radiol. 2007 Feb;18(2):203-7. PubMed PMID: 17327552.

9: Yousefi S, Czeyda-Pommersheim F, White AM, Banovac F, Hahn WY, Spies JB. Repeat uterine artery embolization: indications and technical findings. J Vasc Interv Radiol. 2006 Dec;17(12):1923-9. PubMed PMID: 17185687.

10: Spies JB. Adding to our understanding of uterine fibroid embolization. AJR Am J Roentgenol. 2006 Mar;186(3):846-7. PubMed PMID: 16498119.