SLF1081851
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466283

CAS#: 2763730-97-6 (free base)

Description: SLF1081851 is an In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitor. In vitro studies in HeLa cells demonstrated that SLF1081851 inhibited S1P release with an IC50 of 1.93 μM. Administration of SLF1081851 to mice and rats drove significant decreases in circulating lymphocyte counts and plasma S1P concentrations, recapitulating the phenotype observed in mice made deficient in Spns2. Thus, SLF1081851 has the potential for development and use as a probe to investigate Spns2 biology and to determine the potential of Spns2 as a drug target.


Chemical Structure

img
SLF1081851
CAS# 2763730-97-6 (free base)

Theoretical Analysis

MedKoo Cat#: 466283
Name: SLF1081851
CAS#: 2763730-97-6 (free base)
Chemical Formula: C21H33N3O
Exact Mass: 343.26
Molecular Weight: 343.515
Elemental Analysis: C, 73.43; H, 9.68; N, 12.23; O, 4.66

Price and Availability

Size Price Availability Quantity
5mg USD 350 2 Weeks
10mg USD 550 2 Weeks
Bulk inquiry

Related CAS #: 2763730-97-6 (free base)   SLF1081851 (HCl)  

Synonym: SLF1081851; SLF 1081851; SLF-1081851;

IUPAC/Chemical Name: 3-(3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl)propan-1-amine

InChi Key: VLTITRMWGPJCFJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H33N3O/c1-2-3-4-5-6-7-8-9-11-18-13-15-19(16-14-18)21-23-20(25-24-21)12-10-17-22/h13-16H,2-12,17,22H2,1H3

SMILES Code: CCCCCCCCCCC1=CC=C(C2=NOC(CCCN)=N2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 343.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Fritzemeier R, Foster D, Peralta A, Payette M, Kharel Y, Huang T, Lynch KR, Santos WL. Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. J Med Chem. 2022 Jun 9;65(11):7656-7681. doi: 10.1021/acs.jmedchem.1c02171. Epub 2022 May 24. PMID: 35609189.