FFENM

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465442

CAS#: 1639210-26-6 (free base)

Description: FFENM is a novel potent neuroprotective agent for treatment of Alzheimer's disease (AD), targeting NMDA receptor.

Chemical Structure

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FFENM
CAS# 1639210-26-6 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 465442
Name: FFENM
CAS#: 1639210-26-6 (free base)
Chemical Formula: C12H20FN
Exact Mass: 197.16
Molecular Weight: 197.297
Elemental Analysis: C, 73.05; H, 10.22; F, 9.63; N, 7.10

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1639210-26-6 (free base)   1639210-25-5 (HCl)  

Synonym: FFENM; Fluoroethylnormemantine;

IUPAC/Chemical Name: (1s,3r,5R,7S)-3-(2-fluoroethyl)adamantan-1-amine

InChi Key: HUYVZSFADWYSHD-CDECOKDKSA-N

InChi Code: InChI=1S/C12H20FN/c13-2-1-11-4-9-3-10(5-11)7-12(14,6-9)8-11/h9-10H,1-8,14H2/t9-,10+,11-,12-

SMILES Code: N[C@@]12C[C@@H]3C[C@H](C2)C[C@@](C1)(CCF)C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 197.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chen BK, Luna VM, Shannon ME, Hunsberger HC, Mastrodonato A, Stackmann M, McGowan JC, Rubinstenn G, Denny CA. Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior. Biol Psychiatry. 2021 May 9:S0006-3223(21)01298-1. doi: 10.1016/j.biopsych.2021.04.024. Epub ahead of print. PMID: 34274107.

2: Chen BK, Le Pen G, Eckmier A, Rubinstenn G, Jay TM, Denny CA. Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits. Int J Neuropsychopharmacol. 2021 Jul 14;24(6):519-531. doi: 10.1093/ijnp/pyab007. PMID: 33631001; PMCID: PMC8278800.

3: Couly S, Denus M, Bouchet M, Rubinstenn G, Maurice T. Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease. Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157. doi: 10.1093/ijnp/pyaa075. PMID: 32977336; PMCID: PMC7883897.

4: Salabert AS, Mora-Ramirez E, Beaurain M, Alonso M, Fontan C, Tahar HB, Boizeau ML, Tafani M, Bardiès M, Payoux P. Evaluation of [18F]FNM biodistribution and dosimetry based on whole-body PET imaging of rats. Nucl Med Biol. 2018 Apr;59:1-8. doi: 10.1016/j.nucmedbio.2017.12.003. Epub 2017 Dec 21. PMID: 29413751.

5: Salabert AS, Fonta C, Fontan C, Adel D, Alonso M, Pestourie C, Belhadj-Tahar H, Tafani M, Payoux P. Radiolabeling of [18F]-fluoroethylnormemantine and initial in vivo evaluation of this innovative PET tracer for imaging the PCP sites of NMDA receptors. Nucl Med Biol. 2015 Aug;42(8):643-53. doi: 10.1016/j.nucmedbio.2015.04.001. Epub 2015 Apr 7. PMID: 25963911.