Mefloquine mesylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 577080

CAS#: 64003-26-5 (mesylate)

Description: Mefloquine mesylate is a phospholipid-interacting antimalarial drug.

Chemical Structure

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Mefloquine mesylate
CAS# 64003-26-5 (mesylate)
Instruction

Theoretical Analysis

MedKoo Cat#: 577080
Name: Mefloquine mesylate
CAS#: 64003-26-5 (mesylate)
Chemical Formula: C18H20F6N2O4S
Exact Mass: 474.10
Molecular Weight: 474.420
Elemental Analysis: C, 45.57; H, 4.25; F, 24.03; N, 5.90; O, 13.49; S, 6.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 51773-92-3 (HCl)   53230-10-7 (free base)   64003-26-5 (mesylate)  

Synonym: Mefloquine mesylate; Mefloquine methanesulfonate

IUPAC/Chemical Name: 4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,s*)-(+/-)-, monomethanesulfonate (salt)

InChi Key: GFKKBAFIZVIFAZ-YLCXCWDSSA-N

InChi Code: InChI=1S/C17H16F6N2O.CH4O3S/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;1-5(2,3)4/h3-5,8,12,15,24,26H,1-2,6-7H2;1H3,(H,2,3,4)/t12-,15+;/m1./s1

SMILES Code: CS(=O)(=O)O.O[C@H]([C@H]1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 474.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Goto TE, Caseli L. The interaction of mefloquine hydrochloride with cell membrane models at the air-water interface is modulated by the monolayer lipid composition. J Colloid Interface Sci. 2014 Oct 1;431:24-30. doi: 10.1016/j.jcis.2014.05.050. Epub 2014 Jun 14. PubMed PMID: 24980622.

2: Yadav AV, Dabke AP, Shete AS. Crystal engineering to improve physicochemical properties of mefloquine hydrochloride. Drug Dev Ind Pharm. 2010 Sep;36(9):1036-45. doi: 10.3109/03639041003642065. PubMed PMID: 20334542.

3: Karle JM, Karle IL. Crystal structure of (-)-mefloquine hydrochloride reveals consistency of configuration with biological activity. Antimicrob Agents Chemother. 2002 May;46(5):1529-34. PubMed PMID: 11959592; PubMed Central PMCID: PMC127198.

4: Stockwell JR. Aeromedical considerations of malaria prophylaxis with mefloquine hydrochloride. Aviat Space Environ Med. 1982 Oct;53(10):1011-3. PubMed PMID: 6983345.