Flesinoxan HCl

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MedKoo CAT#: 413950

CAS#: 98205-89-1 (HCl)

Description: Flesinoxan HCl is the salt form of Flesinoxan, which is a selective 5-HT1A receptor agonist.

Chemical Structure

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Flesinoxan HCl
CAS# 98205-89-1 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 413950
Name: Flesinoxan HCl
CAS#: 98205-89-1 (HCl)
Chemical Formula: C22H27ClFN3O4
Exact Mass: 0.00
Molecular Weight: 451.920
Elemental Analysis: C, 58.47; H, 6.02; Cl, 7.84; F, 4.20; N, 9.30; O, 14.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 98205-89-1 (HCl)   98206-10-1 (free base)  

Synonym: Flesinoxan HCl; Flesinoxan hydrochloride; DU29373; DU-29373; DU 29373

IUPAC/Chemical Name: Benzamide, N-(2-(4-((2R)-2,3-dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl)-1-piperazinyl)ethyl)-4-fluoro-, monohydrochloride

InChi Key: LZBWQEXVQZCBDJ-GMUIIQOCSA-N

InChi Code: InChI=1S/C22H26FN3O4.ClH/c23-17-6-4-16(5-7-17)22(28)24-8-9-25-10-12-26(13-11-25)19-2-1-3-20-21(19)29-15-18(14-27)30-20;/h1-7,18,27H,8-15H2,(H,24,28);1H/t18-;/m1./s1

SMILES Code: O=C(NCCN1CCN(C2=C3OC[C@@H](CO)OC3=CC=C2)CC1)C4=CC=C(F)C=C4.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 451.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Monti JM, Jantos H. Effects of the 5-HT1A receptor ligands flesinoxan and WAY 100635 given systemically or microinjected into the laterodorsal tegmental nucleus on REM sleep in the rat. Behav Brain Res. 2004 May 5;151(1-2):159-66. PubMed PMID: 15084431.

2: Bouwknecht JA, van der Gugten J, Groenink L, Olivier B, Paylor RE. Effects of repeated testing in two inbred strains on flesinoxan dose-response curves in three mouse models for anxiety. Eur J Pharmacol. 2004 Jun 21;494(1):35-44. PubMed PMID: 15194449.

3: Bouwknecht JA, van der Gugten J, Groenink L, Olivier B, Paylor RE. Behavioral and physiological mouse models for anxiety: effects of flesinoxan in 129S6/SvEvTac and C57BL/6J mice. Eur J Pharmacol. 2004 Jun 21;494(1):45-53. PubMed PMID: 15194450.

4: Tohyama Y, Mück-Seler D, Diksic M. Acute flesinoxan treatment produces a different effect on rat brain serotonin synthesis than chronic treatment: an alpha-methyl-l-tryptophan autoradiographic study. Neurochem Int. 2007 Dec;51(8):486-95. Epub 2007 May 22. PubMed PMID: 17574706.

5: Tsuji M, Takeda H, Matsumiya T. Modulation of passive avoidance in mice by the 5-HT1A receptor agonist flesinoxan: comparison with the benzodiazepine receptor agonist diazepam. Neuropsychopharmacology. 2003 Apr;28(4):664-74. Epub 2002 Oct 3. PubMed PMID: 12655311.

6: Monti JM, Jantos H. Differential effects of the 5-HT1A receptor agonist flesinoxan given locally or systemically on REM sleep in the rat. Eur J Pharmacol. 2003 Oct 8;478(2-3):121-30. PubMed PMID: 14575796.