Chlormadinone (free base)

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MedKoo CAT#: 413162

CAS#: 1961-77-9 (free base)

Description: Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.

Chemical Structure

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Chlormadinone (free base)
CAS# 1961-77-9 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 413162
Name: Chlormadinone (free base)
CAS#: 1961-77-9 (free base)
Chemical Formula: C21H27ClO3
Exact Mass: 362.16
Molecular Weight: 362.890
Elemental Analysis: C, 69.51; H, 7.50; Cl, 9.77; O, 13.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1961-77-9 (free base)   302-22-7 (acetate)  

Synonym: Chlormadinone (free base); Chlormadinonum; Clormadinona

IUPAC/Chemical Name: Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-

InChi Key: VUHJZBBCZGVNDZ-TTYLFXKOSA-N

InChi Code: InChI=1S/C21H27ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h10-11,14-16,25H,4-9H2,1-3H3/t14-,15+,16+,19-,20+,21+/m1/s1

SMILES Code: CC([C@@]1(O)CC[C@@]2([H])[C@]3([H])C=C(Cl)C4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 362.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Guerra-Tapia A, Sancho Pérez B. Ethinylestradiol/Chlormadinone acetate: dermatological benefits. Am J Clin Dermatol. 2011 Sep 6;12 Suppl 1(Suppl 1):3-11. doi: 10.2165/1153874-S0-000000000-00000. PMID: 21895044; PMCID: PMC7382656.

2: Curran MP, Wagstaff AJ. Ethinylestradiol/chlormadinone acetate. Drugs. 2004;64(7):751-60; discussion 761-2. doi: 10.2165/00003495-200464070-00005. PMID: 15025547.

3: Barriga P P, Ambrosi Penazzo N, Franco Finotti M, Celis AA, Cerdas O, Chávez JA, Cuitiño LA, Fernandes CE, Plata MA, Tirán-Saucedo J, Vanhauwaert PS. At 10 years of chlormadinone use in Latin America: a review. Gynecol Endocrinol. 2016 Jul;32(7):517-20. doi: 10.3109/09513590.2016.1153059. Epub 2016 Apr 26. PMID: 27113551.

4: Bouchard P. Chlormadinone acetate (CMA) in oral contraception--a new opportunity. Eur J Contracept Reprod Health Care. 2005;10 Suppl 1:7-11. doi: 10.1080/13625180500434889. PMID: 16356876.

5: Ishizuka N, Chihara T, Nakanishi T, Iida M, Kitanishi M. [Chlormadinone]. Saishin Igaku. 1965 May;20(5):1180-95. Japanese. PMID: 4161035.

6: Guido M, Romualdi D, Campagna G, Ricciardi L, Bompiani A, Lanzone A. Ethinylestradiol-chlormadinone acetate combination for the treatment of hirsutism and hormonal alterations of normal-weight women with polycystic ovary syndrome: evaluation of the metabolic impact. Reprod Sci. 2010 Aug;17(8):767-75. doi: 10.1177/1933719110371515. PMID: 20595709.

7: Druckmann R. Profile of the progesterone derivative chlormadinone acetate - pharmocodynamic properties and therapeutic applications. Contraception. 2009 Apr;79(4):272-81. doi: 10.1016/j.contraception.2008.10.017. Epub 2009 Jan 17. PMID: 19272496.

8: Zeng J, Chen J, Chen L, Zheng W, Cao Y, Huang T. Enhanced Oral Bioavailability of Chlormadinone Acetate through a Self-Microemulsifying Drug Delivery System for a Potential Dose Reduction. AAPS PharmSciTech. 2018 Nov;19(8):3850-3858. doi: 10.1208/s12249-018-1193-y. Epub 2018 Oct 2. PMID: 30280353.

9: Chlormadinone acetate. IARC Monogr Eval Carcinog Risk Chem Hum. 1979 Dec;21:365-75. PMID: 94586.

10: Zaun H. Chlormadinonacetat als isolierte Therapie [Chlormadinone acetate alone as therapy]. Hautarzt. 1996 Jan;47(1):66. German. doi: 10.1007/s001050050379. PMID: 8835009.