Bunamidine hydrochloride | CAS# 1055-55-6 (HCl)

Bunamidine hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412178

CAS#: 1055-55-6 (HCl)

Description: Bunamidine is a anti-parasitic drug, which was approved by FDA for the treatment of tapeworms in cats and dogs (Scolaban 400 tablets).

Chemical Structure

Bunamidine hydrochloride

CAS# 1055-55-6 (HCl)

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 412178
Name: Bunamidine hydrochloride
CAS#: 1055-55-6 (HCl)
Chemical Formula: C25H39ClN2O
Exact Mass: 0.00
Molecular Weight: 419.050
Elemental Analysis: C, 71.66; H, 9.38; Cl, 8.46; N, 6.69; O, 3.82

Price and Availability

Size	Price	Availability
1mg	USD 90	Ready to ship
5mg	USD 250	Ready to ship
10mg	USD 450	Ready to ship
25mg	USD 950	Ready to ship
50mg	USD 1650	Ready to ship
100mg	USD 2650	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 1055-55-6 (HCl) 3748-77-4 (free base)

Synonym: Bunamidine hydrochloride; Bunamidine HCl; BW62415; BW-62415; BW 62415; Scolaban

IUPAC/Chemical Name: 1-Naphthalenecarboximidamide, N,N-dibutyl-4-(hexyloxy)-, monohydrochloride

InChi Key: PBYJDHRFPFHVKZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H38N2O.ClH/c1-4-7-10-13-20-28-24-17-16-23(21-14-11-12-15-22(21)24)25(26)27(18-8-5-2)19-9-6-3;/h11-12,14-17,26H,4-10,13,18-20H2,1-3H3;1H

SMILES Code: N=C(C1=C2C=CC=CC2=C(OCCCCCC)C=C1)N(CCCC)CCCC.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#S21S12C13

QC Data:

View QC data: current batch, Lot#S21S12C13

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	Bunamidine hydrochloride is a veterinary anti-platyhelmintic agent used for Echinococcus granulosus and Taenia hydatigena.
In vitro activity:	TBD
In vivo activity:	Bunamidine, in the rat heart, caused a dose-dependent decrease in spontaneous heart rate, coronary flow and isometric systolic tension, but increased diastolic tension at 10,000 ng/ml. Bunamidine altered electrical activity by prolonging PR, QRS and QT intervals. It also produced partial heart block and ventricular standstill. Lastly, b unamidine diminished cardiac glycogen, ATP and creatine phosphate and increased tissue content of d-glucose-6-phosphate, l-(−)-glycerol-1-phosphate and lactate. Conversion of phosphorylase b to a was increased. Reference: Gen Pharmacol. 1978;9(2):101-12. https://pubmed.ncbi.nlm.nih.gov/566235/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.3	79.54

Preparing Stock Solutions

The following data is based on the product molecular weight 419.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Trejos A, Szyfres B, Marchevsky N. Comparative value of arecoline hydrobromide and bunamidine hydrochloride for the treatment of Echinococcus granulosus in dogs. Res Vet Sci. 1975 Sep;19(2):212-3. PMID: 1172623. 2. Cruthers LR, Linkenheimer WH, Maplesden DC. Taeniacidal efficacy of SQ 21,704 in dogs by various types of oral administration and in comparison with niclosamide and bunamidine hydrochloride. Am J Vet Res. 1979 May;40(5):676-8. PMID: 573081.
In vitro protocol:	TBD
In vivo protocol:	1. Trejos A, Szyfres B, Marchevsky N. Comparative value of arecoline hydrobromide and bunamidine hydrochloride for the treatment of Echinococcus granulosus in dogs. Res Vet Sci. 1975 Sep;19(2):212-3. PMID: 1172623. 2. Cruthers LR, Linkenheimer WH, Maplesden DC. Taeniacidal efficacy of SQ 21,704 in dogs by various types of oral administration and in comparison with niclosamide and bunamidine hydrochloride. Am J Vet Res. 1979 May;40(5):676-8. PMID: 573081.

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1: Larionova TK, Kudasheva FKh, Bogoliuk GB, Afanaséva LI. Opredelenie promezhutochnykh produktov sinteza bunamidina gidrokhlorida v vozdukhe rabocheĭ rabocheĭ zony metodom vysokoéffectivnoĭ zhidkostnoĭ khromatografii [Evaluation of intermediate products of bunamidine hydrochloride synthesis in the workplace air by high performance liquid chromatography method]. Gig Sanit. 1993 Oct;(10):70-1. Russian. PMID: 8163245.

2: Cruthers LR, Linkenheimer WH, Maplesden DC. Taeniacidal efficacy of SQ 21,704 in dogs by various types of oral administration and in comparison with niclosamide and bunamidine hydrochloride. Am J Vet Res. 1979 May;40(5):676-8. PMID: 573081.

3: Thakur AS, Prezioso U, Marchevsky N. Echinococcus granulosus: ovicidal activity of praziquantel and bunamidine hydrochloride. Exp Parasitol. 1979 Apr;47(2):131-3. doi: 10.1016/0014-4894(79)90066-3. PMID: 571349.

4: Todd KS Jr, Howland TP, Woerpel RW. Activity of uredofos, niclosamide, bunamidine hydrochloride, and arecoline hydrobromide against Mesocestoides corti in experimentally infected dogs. Am J Vet Res. 1978 Feb;39(2):315-6. PMID: 564650.

5: Gemmell MA. The Styx Field Trial: effect of treatment of the definitive host for tapeworms on larval forms in the intermediate host. Bull World Health Organ. 1978;56(3):433-43. PMID: 308408; PMCID: PMC2395586.

6: Roberson EL. Comparative effects of uredofos, niclosamide, and bunamidine hydrochloride against tapeworm infections in dogs. Am J Vet Res. 1976 Dec;37(12):1483-4. PMID: 1033722.

7: King AB. Bunamidine hydrochloride in dogs. J Am Vet Med Assoc. 1976 Nov 1;169(9):854, 856, 858. PMID: 988006.

8: Williams JF, Keahey KK. Sudden death associated with treatment of three dogs with bunamidine hydrochloride. J Am Vet Med Assoc. 1976 Apr 15;168(8):689-91. PMID: 944173.

9: Trejos A, Szyfres B, Marchevsky N. Comparative value of arecoline hydrobromide and bunamidine hydrochloride for the treatment of Echinococcus granulosus in dogs. Res Vet Sci. 1975 Sep;19(2):212-3. PMID: 1172623.

10: Andersen FL, Loveless RM, Jensen LA. Efficacy of bunamidine hydrochloride against immature and mature stages of Echinococcus granulosus. Am J Vet Res. 1975 May;36(5):673-5. PMID: 1169897.

11: Williams GF, Colli CW, Leid RW, MacArthur R. The effects of bunamidine hydrochloride on the infectivity of taeniid ova. J Parasitol. 1973 Dec;59(6):1141-4. PMID: 4796811.

12: Cook BR. A field trial with bunamidine hydrochloride as an anthelmintic in the eradication of Echinococcus granulosus, Taenia hydatigena and Taenia ovis in New Zealand. N Z Vet J. 1970 Aug;18(8):152-5. doi: 10.1080/00480169.1970.33886. PMID: 5273618.

13: Williams JF, Trejos A. The influence of gelatin capsules upon the activity of bunamidine hydrochloride against Echinococcus granulosus in dogs. Res Vet Sci. 1970 Jul;11(4):392-4. PMID: 5499329.

14: Blood BD, Moya V, Lelijveld JL. Evaluation of selected drugs for the treatment of canine echinococcosis. Bull World Health Organ. 1968;39(1):67-72. PMID: 5303842; PMCID: PMC2554388.

15: Forbes LS. The efficiency of bunamidine hydrochloride against young Echinococcus granulosus infection in dogs. Vet Rec. 1966 Sep 10;79(11):306-7. doi: 10.1136/vr.79.11.306. PMID: 5970728.

16: HATTON CJ. A NEW TAENIACIDE, BUNAMIDINE HYDROCHLORIDE: ITS EFFICIENCY AGAINST TAENIA PISIFORMIS AND DIPYLIDIUM CANINUM IN THE DOG AND HYDATIGERA TAENIAEFORMIS IN THE CAT. Vet Rec. 1965 Apr 10;77:408-11. PMID: 14330224.

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