CCRP2
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MedKoo CAT#: 555813

CAS#: 958323-31-4 (free base)

Description: CCRP2, also known as TLX agonist 1 and SUN23314, is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity. CCRP2 was reported in PLoS One . 2014 Jun 17;9(6):e99440.

Chemical Structure

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CCRP2
CAS# 958323-31-4 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 555813
Name: CCRP2
CAS#: 958323-31-4 (free base)
Chemical Formula: C23H26N4O
Exact Mass: 374.21
Molecular Weight: 374.488
Elemental Analysis: C, 73.77; H, 7.00; N, 14.96; O, 4.27

Price and Availability

Size Price Availability Quantity
50mg USD 850 2 Weeks
100mg USD 1450 2 Weeks
200mg USD 2150 2 Weeks
500mg USD 2950 2 Weeks
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Related CAS #: 958323-31-4 (free base)   CCRP2 HCl    

Synonym: TLX agonist 1; SUN23314; SUN-23314; SUN 23314; CCRP2; CCRP-2; CCRP 2;

IUPAC/Chemical Name: (4-benzhydrylpiperazin-1-yl)(1,5-dimethyl-1H-pyrazol-3-yl)methanone

InChi Key: SSGJAUSSGPIZEE-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H26N4O/c1-18-17-21(24-25(18)2)23(28)27-15-13-26(14-16-27)22(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-12,17,22H,13-16H2,1-2H3

SMILES Code: O=C(C1=NN(C)C(C)=C1)N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Nuclear receptors (NRs) are an important group of ligand-dependent transcriptional factors. Presently, no natural or synthetic ligand has been identified for a large group of orphan NRs. Small molecules to target these orphan NRs will provide unique resources for uncovering regulatory systems that impact human health and to modulate these pathways with drugs. The orphan NR tailless (TLX, NR2E1), a transcriptional repressor, is a major player in neurogenesis and Neural Stem Cell (NSC) derived brain tumors. No chemical probes that modulate TLX activity are available, and it is not clear whether TLX is druggable.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 374.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Benod C, Villagomez R, Filgueira CS, et al. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable. PLoS One. 2014;9(6):e99440. Published 2014 Jun 17. doi:10.1371/journal.pone.0099440