Quipazine dimaleate
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MedKoo CAT#: 574385

CAS#: 150323-78-7 (maleate)

Description: Quipazine dimaleate is a selective 5-HT3 receptor agonist that also displays antagonist activity at peripheral 5-HT3 receptors. [3H]-Quipazine labels 5-HT3 sites in the cortical membranes.

Chemical Structure

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Quipazine dimaleate
CAS# 150323-78-7 (maleate)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 574385
Name: Quipazine dimaleate
CAS#: 150323-78-7 (maleate)
Chemical Formula: C21H23N3O8
Exact Mass: 0.00
Molecular Weight: 445.430
Elemental Analysis: C, 56.63; H, 5.20; N, 9.43; O, 28.73

Price and Availability

Size Price Availability Quantity
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1350 2 Weeks
1g USD 2250 2 Weeks
2g USD 3850 2 Weeks
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Related CAS #: 4774-24-7 (free base)   150323-78-7 (maleate)    

Synonym: Quipazine dimaleate

IUPAC/Chemical Name: 2-(1-Piperazinyl)quinoline dimaleate

InChi Key: VAOSOCRJSSWBEQ-SPIKMXEPSA-N

InChi Code: InChI=1S/C13H15N3.2C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;2*5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

SMILES Code: OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C1CN(CCN1)C1=NC2=C(C=CC=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in water

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Quipazine dimaleate is a salt.
In vitro activity: To be determined
In vivo activity: Macronutrient intakes, 2h and 12h, following administration of quipazine were examined in three groups of adult male and female Wistar rats. Quipazine injection reduced carbohydrate ingestion from corn starch-containing diets in male and female rats. This study found that the nature of the macronutrient source is important to assess the effect of a drug on nutrient-specific selection. Reference: Appetite. 2000 Jun;34(3):313-25. https://pubmed.ncbi.nlm.nih.gov/10888295/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Water 44.5 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 445.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Mok E, Paquette M, Thibault L. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. doi: 10.1006/appe.2000.0321. PMID: 10888295. 2. Bonson KR, Winter JC. Reversal of testosterone-induced dominance by the serotonergic agonist quipazine. Pharmacol Biochem Behav. 1992 Aug;42(4):809-13. doi: 10.1016/0091-3057(92)90034-d. PMID: 1513863.
In vitro protocol:
In vivo protocol: 1. Mok E, Paquette M, Thibault L. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. doi: 10.1006/appe.2000.0321. PMID: 10888295. 2. Bonson KR, Winter JC. Reversal of testosterone-induced dominance by the serotonergic agonist quipazine. Pharmacol Biochem Behav. 1992 Aug;42(4):809-13. doi: 10.1016/0091-3057(92)90034-d. PMID: 1513863.

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1. Ireland and Tyers (1987) Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br.J.Pharmacol. 90 229 PMID: 3814920

2. Peroutka and Hamik (1988) [3H]Quipazine labels 5-HT3 recognition sites in rat cortical membranes. Eur.J.Pharmacol. 148 297 PMID: 3378579

3. Sharif et al (1991) Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. Br.J.Pharmacol. 102 919 PMID: 1830236