Remdesivir maleate

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MedKoo CAT#: 462170

CAS#: 2250110-53-1 (maleate)

Description: Remdesivir, also known as GS-5734, is a prodrug form of the antiviral nucleoside analog GS-44152. It was developed as a treatment for filovirus infections such as Ebola virus disease and Marburg virus. Remdesivir was approved for treatment of COVID-19.

Chemical Structure

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Remdesivir maleate
CAS# 2250110-53-1 (maleate)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 462170
Name: Remdesivir maleate
CAS#: 2250110-53-1 (maleate)
Chemical Formula: C31H39N6O12P
Exact Mass: 0.00
Molecular Weight: 718.656
Elemental Analysis: C, 51.81; H, 5.47; N, 11.69; O, 26.71; P, 4.31

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1809249-37-3 (free base)   2250110-53-1 (maleate)  

Synonym: Remdesivir maleate; GS-5734; GS5734; GS 5734;

IUPAC/Chemical Name: (S)-2-Ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate maleate

InChi Key: SHXZEGNLALLKFB-OOHSPWKBSA-N

InChi Code: InChI=1S/C27H35N6O8P.C4H4O4/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22;5-3(6)1-2-4(7)8/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31);1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,21+,23+,24+,27-,42?;/m0./s1

SMILES Code: C[C@H](NP(OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O)C(OCC(CC)CC)=O.O=C(O)/C=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >3 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Upon entry into cells, remdesivir metabolizes into the nucleotide triphosphate GS-441524. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h. Remdesivir inhibits both epidemic and zoonotic coronaviruses.
In vitro activity: The combination treatment of remdesivir plus chloroquine resulted in an antagonistic interaction in normal human bronchial epithelial cells. The findings of this study indicate that the combined use of interferon-β plus remdesivir induces maximal antiviral activity against human coronavirus strain OC43 in primary human respiratory epithelial cells. Reference: J Interferon Cytokine Res. 2023 Jan;43(1):35-42. https://pubmed.ncbi.nlm.nih.gov/36651846/
In vivo activity: Remdesivir treatment can restore the levels of miRNAs that are upregulated in COVID-19 patients to the range observed in healthy subjects. Three miRNAs (hsa-miR-7-5p, hsa-miR-10b-5p, and hsa-miR-130b-3p) were found to be upregulated in patients receiving remdesivir treatment and in patients who experienced natural remission. These upregulated miRNAs could serve as biomarkers of COVID-19 remission. Reference: Arch Virol. 2023 Jun 28;168(7):194. https://pubmed.ncbi.nlm.nih.gov/37380930/

Preparing Stock Solutions

The following data is based on the product molecular weight 718.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Hickerson BT, Sheikh F, Donnelly RP, Ilyushina NA. Comparison of the Antiviral Activity of Remdesivir, Chloroquine, and Interferon-β as Single or Dual Agents Against the Human Beta-Coronavirus OC43. J Interferon Cytokine Res. 2023 Jan;43(1):35-42. doi: 10.1089/jir.2022.0210. PMID: 36651846; PMCID: PMC9885548. 2. Lee CM, Kang MA, Bae JS, Park K, Yang YH, Lee J, Jang KY, Park SH. An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257. PMID: 35417658. 3. Fayyad-Kazan M, Makki R, Homsi ME, Samadi A, Chaaban H, Majzoub RE, Hamade E, Fayyad-Kazan H, Badran B. Circulating microRNA profile in response to remdesivir treatment in coronavirus disease 2019 (COVID-19) patients. Arch Virol. 2023 Jun 28;168(7):194. doi: 10.1007/s00705-023-05825-3. PMID: 37380930. 4. Chen Y, Guo Y, Li S, Xu J, Ning W, Zhao C, Wang J, Qu Y, Zhang M, Zhou W, Cui Q, Zhang H. Remdesivir inhibits the progression of glioblastoma by enhancing endoplasmic reticulum stress. Biomed Pharmacother. 2023 Jan;157:114037. doi: 10.1016/j.biopha.2022.114037. Epub 2022 Nov 22. PMID: 36427388.
In vitro protocol: 1. Hickerson BT, Sheikh F, Donnelly RP, Ilyushina NA. Comparison of the Antiviral Activity of Remdesivir, Chloroquine, and Interferon-β as Single or Dual Agents Against the Human Beta-Coronavirus OC43. J Interferon Cytokine Res. 2023 Jan;43(1):35-42. doi: 10.1089/jir.2022.0210. PMID: 36651846; PMCID: PMC9885548. 2. Lee CM, Kang MA, Bae JS, Park K, Yang YH, Lee J, Jang KY, Park SH. An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257. PMID: 35417658.
In vivo protocol: 1. Fayyad-Kazan M, Makki R, Homsi ME, Samadi A, Chaaban H, Majzoub RE, Hamade E, Fayyad-Kazan H, Badran B. Circulating microRNA profile in response to remdesivir treatment in coronavirus disease 2019 (COVID-19) patients. Arch Virol. 2023 Jun 28;168(7):194. doi: 10.1007/s00705-023-05825-3. PMID: 37380930. 2. Chen Y, Guo Y, Li S, Xu J, Ning W, Zhao C, Wang J, Qu Y, Zhang M, Zhou W, Cui Q, Zhang H. Remdesivir inhibits the progression of glioblastoma by enhancing endoplasmic reticulum stress. Biomed Pharmacother. 2023 Jan;157:114037. doi: 10.1016/j.biopha.2022.114037. Epub 2022 Nov 22. PMID: 36427388.

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1: Siegel D, Hui HC, Doerffler E, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017;60(5):1648‐1661. doi:10.1021/acs.jmedchem.6b01594