Pemedolac sodium

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MedKoo CAT#: 573357

CAS#: 148129-69-5 (sodium)

Description: Pemedolac, also known as Dexpemedolac and AY-30,715, is a potent analgesic agent. Pemedolac exhibited potent analgesic effects against chemically induced pain in rats and mice and against inflammatory pain in rats. Pemedolac differed from standard nonsteroidal anti-inflammatory drugs (NSAIDs) in that the doses which produced analgesia were much lower than those required for either anti-inflammatory or gastric irritant effects.

Chemical Structure

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Pemedolac sodium
CAS# 148129-69-5 (sodium)
Instruction

Theoretical Analysis

MedKoo Cat#: 573357
Name: Pemedolac sodium
CAS#: 148129-69-5 (sodium)
Chemical Formula: C22H22NNaO3
Exact Mass: 349.17
Molecular Weight: 371.410
Elemental Analysis: C, 71.15; H, 5.97; N, 3.77; Na, 6.19; O, 12.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 148129-69-5 (sodium)   114716-16-4 (free acid)   114030-44-3   114030-45-4    

Synonym: AY-30,715; AY 30,715; AY30,715; AY-30715; AY 30715; AY30715; pemedolac; WAY-PEM-420; Dexpemedolac

IUPAC/Chemical Name: Pyrano[3,4-b]indole-1-acetic acid, 1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)-, sodium salt (1:1), (1R,4S)-rel-

InChi Key: FRXLWASFNBDPHC-BYYQELCVSA-M

InChi Code: InChI=1S/C22H23NO3.Na/c1-2-22(13-19(24)25)21-20(17-10-6-7-11-18(17)23-21)16(14-26-22)12-15-8-4-3-5-9-15;/h3-11,16,23H,2,12-14H2,1H3,(H,24,25);/q;+1/p-1/t16-,22-;/m1./s1

SMILES Code: O=C([O-])C[C@@]1(CC)OC[C@@H](CC2=CC=CC=C2)C3=C1NC4=C3C=CC=C4.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 371.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Catalano A, Iacopetta D, Ceramella J, Saturnino C, Sinicropi MS. A Comprehensive Review on Pyranoindole-containing Agents. Curr Med Chem. 2022;29(21):3667-3683. doi: 10.2174/0929867328666211206111058. PMID: 34872472.


2: Chau T, Walter T, Zimmerman J, Hartman D, Ochalski S, Weichman B. Analgesic activities of PEM-420, the active eutomer of pemedolac. Agents Actions. 1993;39 Spec No:C27-9. doi: 10.1007/BF01972710. PMID: 8273576.


3: Chau TT, Weichman BM. Pemedolac: a novel and long-acting non-narcotic analgesic. J Pharmacol Exp Ther. 1989 Mar;248(3):907-15. PMID: 2703977.


4: Mobilio D, Humber LG, Katz AH, Demerson CA, Hughes P, Brigance R, Conway K, Shah U, Williams G, Labbadia F, et al. Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indo le-1-a cetic acid, a potent analgesic agent. J Med Chem. 1988 Nov;31(11):2211-7. doi: 10.1021/jm00119a024. PMID: 3263504.


5: Katz AH, Demerson CA, Shaw CC, Asselin AA, Humber LG, Conway KM, Gavin G, Guinosso C, Jensen NP, Mobilio D, et al. Synthesis and analgesic activity of pemedolac (cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]ind ole-1- acetic acid). J Med Chem. 1988 Jun;31(6):1244-50. doi: 10.1021/jm00401a029. PMID: 3373493.