Endoxifen E-isomer HCl | CAS#1197194-61-8

Endoxifen E-isomer HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555212

CAS#: 1197194-61-8 (E-isomer HCl)

Description: Endoxifen E-isomer is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

Chemical Structure

Endoxifen E-isomer HCl

CAS# 1197194-61-8 (E-isomer HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 555212
Name: Endoxifen E-isomer HCl
CAS#: 1197194-61-8 (E-isomer HCl)
Chemical Formula: C25H28ClNO2
Exact Mass: 0.00
Molecular Weight: 409.954
Elemental Analysis: C, 73.25; H, 6.88; Cl, 8.65; N, 3.42; O, 7.81

Price and Availability

Size	Price	Availability
100mg	USD 950	2 weeks
200mg	USD 1450	2 weeks
500mg	USD 2150	2 weeks
1g	USD 3250	2 weeks
2g	USD 5450	2 weeks
5g	USD 7450	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 1032008-74-4 (HCl) 112093-28-4 (free base) 1372937-28-4 (citrate) 1032008-66-4 (acetate) 1032008-71-1 (mesylate) 1197194-61-8 (E-isomer HCl)

Synonym: Endoxifen E-isomer HCl;

IUPAC/Chemical Name: 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;hydrochloride

InChi Key: RPFIMPDXTABYCN-QREUMGABSA-N

InChi Code: InChI=1S/C25H27NO2.ClH/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;/h4-16,26-27H,3,17-18H2,1-2H3;1H/b25-24+;

SMILES Code: OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 409.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ford BM, Franks LN, Radominska-Pandya A, Prather PL. Tamoxifen Isomers and
Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors:
Potential Scaffold for Drug Development. PLoS One. 2016 Dec 9;11(12):e0167240.
doi: 10.1371/journal.pone.0167240. eCollection 2016. PubMed PMID: 27936172;
PubMed Central PMCID: PMC5147891.

2: Elkins P, Coleman D, Burgess J, Gardner M, Hines J, Scott B, Kroenke M, Larson
J, Lightner M, Turner G, White J, Liu P. Characterization of the
isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution
LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.
doi: 10.1016/j.jpba.2013.07.010. Epub 2013 Jul 24. PubMed PMID: 24055701; PubMed
Central PMCID: PMC4057282.

3: Fauq AH, Maharvi GM, Sinha D. A convenient synthesis of
(Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen). Bioorg Med Chem Lett. 2010 May
15;20(10):3036-8. doi: 10.1016/j.bmcl.2010.03.117. Epub 2010 Apr 3. PubMed PMID:
20400308.

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