NVP ACQ090

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MedKoo CAT#: 532376

CAS#: 362612-47-3 (free base)

Description: NVP ACQ090 is a novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonist.

Chemical Structure

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NVP ACQ090
CAS# 362612-47-3 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 532376
Name: NVP ACQ090
CAS#: 362612-47-3 (free base)
Chemical Formula: C30H40F2N4O2
Exact Mass: 526.31
Molecular Weight: 526.670
Elemental Analysis: C, 68.42; H, 7.66; F, 7.21; N, 10.64; O, 6.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 649761-71-7 (tartrate)   362612-47-3 (free base)   1221509-66-5 (fumarate)    

Synonym: NVP ACQ090; NVPACQ090; NVP-ACQ090; ACQ090; ACQ-090; ACQ 090;

IUPAC/Chemical Name: [(4S,4aS,8aR)-2-[3-(6-methoxypyridin-3-yl)-2-methylpropyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-4-yl]-[4-(3,4-difluorophenyl)piperazin-1-yl]methanone

InChi Key: RDSAUPRYZCQORM-RIVQXRJNSA-N

InChi Code: InChI=1S/C30H40F2N4O2/c1-21(15-22-7-10-29(38-2)33-17-22)18-34-19-23-5-3-4-6-25(23)26(20-34)30(37)36-13-11-35(12-14-36)24-8-9-27(31)28(32)16-24/h7-10,16-17,21,23,25-26H,3-6,11-15,18-20H2,1-2H3/t21?,23-,25-,26+/m0/s1

SMILES Code: O=C([C@@H]1CN(CC(C)CC2=CC=C(OC)N=C2)C[C@]3([H])CCCC[C@]13[H])N4CCN(C5=CC=C(F)C(F)=C5)CC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 526.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lehmann A, Kliewer A, Günther T, Nagel F, Schulz S. Identification of Phosphorylation Sites Regulating sst3 Somatostatin Receptor Trafficking. Mol Endocrinol. 2016 Jun;30(6):645-59. doi: 10.1210/me.2015-1244. Epub 2016 Apr 21. PubMed PMID: 27101376.

2: Einstein EB, Patterson CA, Hon BJ, Regan KA, Reddi J, Melnikoff DE, Mateer MJ, Schulz S, Johnson BN, Tallent MK. Somatostatin signaling in neuronal cilia is critical for object recognition memory. J Neurosci. 2010 Mar 24;30(12):4306-14. doi: 10.1523/JNEUROSCI.5295-09.2010. PubMed PMID: 20335466; PubMed Central PMCID: PMC3842454.

3: Troxler T, Hurth K, Schuh KH, Schoeffter P, Langenegger D, Enz A, Hoyer D. Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1728-34. doi: 10.1016/j.bmcl.2010.01.063. Epub 2010 Jan 21. PubMed PMID: 20137944.