Dersalazine sodium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328043

CAS#: 367249-56-7 (sodium)

Description: Dersalazine, also known as UR-12746, is a PAF antagonist and TNFα inhibitor potentially for the treatment of ulcerative colitis. UR-12746S showed anti-inflammatory effect in reactivated colitis in rats, as evidenced by a significant reduction in MPO activity.

Chemical Structure

img
Dersalazine sodium
CAS# 367249-56-7 (sodium)
Instruction

Theoretical Analysis

MedKoo Cat#: 328043
Name: Dersalazine sodium
CAS#: 367249-56-7 (sodium)
Chemical Formula: C35H31N6NaO4
Exact Mass: 600.25
Molecular Weight: 622.661
Elemental Analysis: C, 67.51; H, 5.02; N, 13.50; Na, 3.69; O, 10.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 367249-56-7 (sodium)   188913-58-8 (free acid)    

Synonym: Dersalazine; UR-12746; UR-12746S (sodium salt); UR12746; UR 12746S (sodium salt).

IUPAC/Chemical Name: sodium 2-hydroxy-5-((E)-(4-((Z)-3-(4-((2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl)piperidin-1-yl)-3-oxo-1-phenylprop-1-en-1-yl)phenyl)diazenyl)benzoate

InChi Key: YLEYSRAGECECMB-UUHDFEAYSA-M

InChi Code: InChI=1S/C35H32N6O4.Na/c1-23-37-31-21-36-16-13-32(31)41(23)22-24-14-17-40(18-15-24)34(43)20-29(25-5-3-2-4-6-25)26-7-9-27(10-8-26)38-39-28-11-12-33(42)30(19-28)35(44)45;/h2-13,16,19-21,24,42H,14-15,17-18,22H2,1H3,(H,44,45);/q;+1/p-1/b29-20-,39-38+;

SMILES Code: O=C(O[Na])C1=CC(/N=N/C2=CC=C(/C(C3=CC=CC=C3)=C\C(N4CCC(CN5C(C)=NC6=C5C=CN=C6)CC4)=O)C=C2)=CC=C1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 367249-56-7 (Dersalazine sodium) 188913-58-8 (Dersalazine free acid)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 622.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x