Flutroline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525070

CAS#: 70801-02-4

Description: Flutroline is a gamma-carboline antipsychotic agent.

Chemical Structure

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Flutroline
CAS# 70801-02-4
Instruction

Theoretical Analysis

MedKoo Cat#: 525070
Name: Flutroline
CAS#: 70801-02-4
Chemical Formula: C27H25F3N2O
Exact Mass: 450.19
Molecular Weight: 450.500
Elemental Analysis: C, 71.98; H, 5.59; F, 12.65; N, 6.22; O, 3.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Flutroline; CP-36,584; Flutrolino; Flutrolinum; CP36,584; flutroline; flutroline, (+-)-isomer.

IUPAC/Chemical Name: (+-)-8-Fluoro-alpha,5-bis(p-fluorophenyl)-1,3,4,5-tetrahydro-2H-pyrido(4,3-b)indole-2-butanol

InChi Key: OYGDOCFZQVGFIP-MHZLTWQESA-N

InChi Code: InChI=1S/C27H25F3N2O/c28-19-5-3-18(4-6-19)27(33)2-1-14-31-15-13-26-24(17-31)23-16-21(30)9-12-25(23)32(26)22-10-7-20(29)8-11-22/h3-12,16,27,33H,1-2,13-15,17H2/t27-/m0/s1

SMILES Code: n1(c2c(C[N@@](CCC[C@@H](c3ccc(F)cc3)O)CC2)c2c1ccc(c2)F)c1ccc(F)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 450.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lehmann J, Knoch F, Jiang N. [Indoles. 10. Synthesis, structure and D2-affinity of beta-carboline analogs of flutroline]. Arch Pharm (Weinheim). 1993 Dec;326(12):947-51. German. PubMed PMID: 7907210.

2: Sarges R, Howard HR, Donahue KM, Welch WM, Dominy BW, Weissman A, Koe BK, Bordner J. Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines. J Med Chem. 1986 Jan;29(1):8-19. Erratum in: J Med Chem 1986 May;29(5):876. PubMed PMID: 3941416.

3: Falkner FC, Fouda HG, Mullins FG. A gas chromatographic/mass spectrometric assay for flutroline, a gamma-carboline antipsychotic agent, with direct derivatization on a moving needle injector. Biomed Mass Spectrom. 1984 Sep;11(9):482-5. PubMed PMID: 6150732.

4: Kurland AA, Nagaraju A, Hanlon TE, Williams TG. The prolactin response to flutroline hydrochloride in schizophrenic patients. J Clin Pharmacol. 1983 Nov-Dec;23(11-12):505-16. PubMed PMID: 6141186.

5: Kurland AA, Nagaraju A, Hanlon TE. Flutroline in the treatment of the schizophrenic patient. J Clin Pharmacol. 1982 Oct;22(10):441-9. PubMed PMID: 6129266.

6: Welch WM, Ewing FE, Harbert CA, Weissman A, Koe BK. 4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3 ,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic. J Med Chem. 1980 Aug;23(8):949-52. PubMed PMID: 6105220.

7: Harbert CA, Plattner JJ, Welch WM, Weissman A, Koe BK. Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines. J Med Chem. 1980 Jun;23(6):635-43. PubMed PMID: 6104732.

8: McEvoy JP, Berney S, Wilson WH, Ban TA, Guy W. A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia. Int Pharmacopsychiatry. 1980;15(5):318-24. PubMed PMID: 7021452.

9: Fink M, Irwin P. EEG and behavioral profile of flutroline (CP-36,584), a novel antipsychotic drug. Psychopharmacology (Berl). 1980;72(1):67-71. PubMed PMID: 6110218.