LAS101057
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MedKoo CAT#: 526720

CAS#: 925676-48-8

Description: LAS101057 is a Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. (last updated: 6/30/2016). LAS101057 inhibits agonist-induced IL-6 production in human fibroblasts and is active in an ovalbumin (OVA)-sensitized mouse model after oral administration, reducing airway hyperresponsiveness to methacholine, Th2 cytokine production, and OVA-specific IgE levels.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 400 2 Weeks
50mg USD 720 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

LAS101057, purity > 95%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526720
Name: LAS101057
CAS#: 925676-48-8
Chemical Formula: C18H14FN5O
Exact Mass: 335.1182
Molecular Weight: 335.3424
Elemental Analysis: C, 64.47; H, 4.21; F, 5.67; N, 20.88; O, 4.77


Synonym: LAS101057; LAS-101057; LAS 101057.

IUPAC/Chemical Name: N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide

InChi Key: XUYURJQIMYCWBB-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14FN5O/c19-14-9-21-7-5-13(14)17-16(12-2-1-6-20-8-12)23-15(10-22-17)24-18(25)11-3-4-11/h1-2,5-11H,3-4H2,(H,23,24,25)

SMILES Code: O=C(C1CC1)NC2=NC(C3=CC=CN=C3)=C(C4=C(F)C=NC=C4)N=C2


Technical Data

Appearance:
Solid powder

Purity:
>95% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Eastwood P, Esteve C, González J, Fonquerna S, Aiguadé J, Carranco I, Doménech
T, Aparici M, Miralpeix M, Albertí J, Córdoba M, Fernández R, Pont M, Godessart
N, Prats N, Loza MI, Cadavid MI, Nueda A, Vidal B. Discovery of LAS101057: A
Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS
Med Chem Lett. 2010 Dec 20;2(3):213-8. doi: 10.1021/ml100249e. eCollection 2011
Mar 10. PubMed PMID: 24900298; PubMed Central PMCID: PMC4018059.