Febantel
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525041

CAS#: 58306-30-2

Description: Febantel is an oral anthelmintic. It is a prodrug metabolised in vivo to fenbendazole. Febantel is used for the treatment and control of gastro-intestinal roundworms, lung worms and tapeworms.


Chemical Structure

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Febantel
CAS# 58306-30-2

Theoretical Analysis

MedKoo Cat#: 525041
Name: Febantel
CAS#: 58306-30-2
Chemical Formula: C20H22N4O6S
Exact Mass: 446.13
Molecular Weight: 446.480
Elemental Analysis: C, 53.80; H, 4.97; N, 12.55; O, 21.50; S, 7.18

Price and Availability

Size Price Availability Quantity
1g USD 250
2g USD 450 2 Weeks
5g USD 850 2 Weeks
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Synonym: Febantel; Rintal; Bay Vh 5757; Febantelum [INN-Latin]; BAY Vh5757; Febantelum; Combotel; Oratel; Negabot Plus; Paste; Rintal (TN); Febantel (USAN/INN).

IUPAC/Chemical Name: ((2-((Methoxyacetyl)amino)-4-(phenylthio)phenyl)carbonimidoyl)bis(carbamic acid), dimethyl ester

InChi Key: HMCCXLBXIJMERM-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H22N4O6S/c1-28-12-17(25)21-16-11-14(31-13-7-5-4-6-8-13)9-10-15(16)22-18(23-19(26)29-2)24-20(27)30-3/h4-11H,12H2,1-3H3,(H,21,25)(H2,22,23,24,26,27)

SMILES Code: c1(c(\N=C(\NC(OC)=O)NC(OC)=O)ccc(c1)Sc1ccccc1)NC(COC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 446.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Klausz G, Keller É, Sára Z, Székely-Körmöczy P, Laczay P, Ary K, Sótonyi P, Róna K. Simultaneous determination of praziquantel, pyrantel embonate, febantel and its active metabolites, oxfendazole and fenbendazole, in dog plasma by liquid chromatography/mass spectrometry. Biomed Chromatogr. 2015 Dec;29(12):1859-65. doi: 10.1002/bmc.3507. Epub 2015 Jun 24. PubMed PMID: 26104502.

2: Piantavini MS, Pontes FL, Uber CP, Stremel DP, Sena MM, Pontarolo R. Chemometric quality inspection control of pyrantel pamoate, febantel and praziquantel in veterinary tablets by mid infrared spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 2014 May 5;125:396-403. doi: 10.1016/j.saa.2014.01.078. Epub 2014 Jan 24. PubMed PMID: 24566119.

3: De Jaeghere W, De Geest BG, Van Bocxlaer J, Remon JP, Vervaet C, Antunes da Fonseca A. Formulation of poorly water-soluble drugs via coacervation--a pilot study using febantel. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):930-5. doi: 10.1016/j.ejpb.2013.07.006. Epub 2013 Jul 18. PubMed PMID: 23872178.

4: Taweethavonsawat P, Chungpivat S, Satranarakun P, Traub RJ, Schaper R. Efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs. Parasitol Res. 2010 Jan;106(2):533-7. doi: 10.1007/s00436-009-1665-9. Epub 2009 Nov 13. PubMed PMID: 19911198.

5: Olson ME, Heine J. Synergistic effect of febantel and pyrantel embonate in elimination of Giardia in a gerbil model. Parasitol Res. 2009 Aug;105 Suppl 1:S135-40. doi: 10.1007/s00436-009-1504-z. PubMed PMID: 19575234.

6: Montoya A, Dado D, Mateo M, Espinosa C, Miró G. Efficacy of Drontal Flavour Plus (50 mg praziquantel, 144 mg pyrantel embonate, 150 mg febantel per tablet) against Giardia sp in naturally infected dogs. Parasitol Res. 2008 Oct;103(5):1141-4. doi: 10.1007/s00436-008-1107-0. Epub 2008 Jul 26. PubMed PMID: 18661153.

7: Schenker R, Cody R, Strehlau G, Alexander D, Junquera P. Comparative effects of milbemycin oxime-based and febantel-pyrantel embonate-based anthelmintic tablets on Toxocara canis egg shedding in naturally infected pups. Vet Parasitol. 2006 Apr 30;137(3-4):369-73. Epub 2006 Feb 21. PubMed PMID: 16490320.

8: Scorza AV, Radecki SV, Lappin MR. Efficacy of a combination of febantel, pyrantel, and praziquantel for the treatment of kittens experimentally infected with Giardia species. J Feline Med Surg. 2006 Feb;8(1):7-13. Epub 2005 Jul 11. PubMed PMID: 16011902.

9: Dusi G, Gamba V, Faggionato E. Rapid determination of the antiparasitic drugs flubendazole and febantel in feeds by HPLC with ultraviolet detection. J Pharm Biomed Anal. 2005 Jun 15;38(2):375-9. Epub 2005 Feb 16. PubMed PMID: 15925235.

10: Prelezov PN, Bauer C. Comparative efficacy of flubendazole chewable tablets and a tablet combination of febantel, pyrantel embonate and praziquantel against Trichuris vulpis in experimentally infected dogs. Dtsch Tierarztl Wochenschr. 2003 Oct;110(10):419-21. PubMed PMID: 14650738.

11: Mehlhorn H, Hanser E, Harder A, Hansen O, Mencke N, Schaper R. Synergistic effects of pyrantel and the febantel metabolite fenbendazole on adult Toxocara canis. Parasitol Res. 2003 Jul;90 Suppl 3:S151-3. Epub 2003 Aug 19. PubMed PMID: 12928887.

12: Mehlhorn H, Hanser E, Harder A, Hansen O, Mencke N, Schaper R. A light and electron microscopic study on the synergistic effect of pyrantel and the febantel metabolite febendazole on adult Toxocara canis in vitro. Parasitol Res. 2003 Jul;90(4):305-13. Epub 2003 Apr 1. PubMed PMID: 12684883.

13: Giangaspero A, Traldi G, Paoletti B, Traversa D, Bianciardi P. Efficacy of pyrantel embonate, febantel and praziquantel against Giardia species in naturally infected adult dogs. Vet Rec. 2002 Feb 9;150(6):184-6. PubMed PMID: 11888112.

14: Payne PA, Ridley RK, Dryden MW, Bathgate C, Milliken GA, Stewart PW. Efficacy of a combination febantel-praziquantel-pyrantel product, with or without vaccination with a commercial Giardia vaccine, for treatment of dogs with naturally occurring giardiasis. J Am Vet Med Assoc. 2002 Feb 1;220(3):330-3. PubMed PMID: 11829263.

15: Barr SC, Bowman DD, Frongillo MF, Joseph SL. Efficacy of a drug combination of praziquantel, pyrantel pamoate, and febantel against giardiasis in dogs. Am J Vet Res. 1998 Sep;59(9):1134-6. PubMed PMID: 9736391.

16: Mehlhorn H, Harder A. Effects of the synergistic action of febantel and pyrantel on the nematode Heterakis spumosa: a light and transmission electron microscopy study. Parasitol Res. 1997;83(5):419-34. PubMed PMID: 9197388.

17: Ben-Zvi Z, Gussarsky E, van Creveld C, Yagil R. The bioavailability of febantel in dehydrated camels. J Vet Pharmacol Ther. 1996 Aug;19(4):288-94. PubMed PMID: 8866457.

18: Chartier C, Kulo A, Delatour P, Cabaret J. [Esophageal closure and the efficacy of febantel against Muellerius capillaris in goats]. Can Vet J. 1995 Nov;36(11):714-6. French. PubMed PMID: 8590430; PubMed Central PMCID: PMC1687018.

19: Landuyt J, Debackere M, Vercruysse J, McKellar Q. The influence of a heavy infection with sensitive and resistant strains of Ostertagia circumcincta and with Trichostrongylus colubriformis on the pharmacokinetics of febantel in lambs. J Vet Pharmacol Ther. 1995 Jun;18(3):180-6. PubMed PMID: 7674453.

20: Chartier C, Kulo A, Cabaret J, Pors I, Benoit C. Individual fluctuations in efficacy of febantel against Muellerius capillaris in goats. Vet Res. 1995;26(2):116-23. PubMed PMID: 7735302.