WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406780
Description: MS-073, also known as CP-162398, is a P-glycoprotein inhibitor (P-gp). MS-073 was compared with verapamil with regard to its ability to overcome MDR in vitro and in vivo. MS-073 at 0.1 microM almost completely reversed in vitro resistance to vincristine (VCR) in VCR-resistant P388 cells. MS-073 also reversed in vitro VCR, adriamycin (ADM), etoposide, and actinomycin D resistance in ADM-resistant human myelogenous leukemia K562 (K562/ADM) cells, MS-073 reverses MDR by competitively inhibiting drug binding to P-glycoprotein.
MedKoo Cat#: 406780
Chemical Formula: C31H33N3O2
Exact Mass: 479.2573
Molecular Weight: 479.624
Elemental Analysis: C, 77.63; H, 6.94; N, 8.76; O, 6.67
This product is not in stock, which may be available by custom synthesis.
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Synonym: MS-073; MS073; MS 073; CP-162398; CP162398; CP 162398.
IUPAC/Chemical Name: 1-(Quinolin-5-yloxy)-3-[4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten)-5-yl]piperazin-1-yl]-2-propanol
InChi Key: YLQSXCMKFKBZLE-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H33N3O2/c35-25(22-36-30-13-5-12-29-28(30)11-6-16-32-29)21-33-17-19-34(20-18-33)31-26-9-3-1-7-23(26)14-15-24-8-2-4-10-27(24)31/h1-13,16,25,31,35H,14-15,17-22H2
SMILES Code: OC(CN1CCN(C2C3=CC=CC=C3CCC4=CC=CC=C24)CC1)COC5=C6C=CC=NC6=CC=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 479.624 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Smith BJ, Doran AC, McLean S, Tingley FD 3rd, O'Neill BT, Kajiji SM.
P-glycoprotein efflux at the blood-brain barrier mediates differences in brain
disposition and pharmacodynamics between two structurally related neurokinin-1
receptor antagonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1252-9. PubMed PMID:
2: Sato W, Fukazawa N, Suzuki T, Yusa K, Tsuruo T. Circumvention of multidrug
resistance by a newly synthesized quinoline derivative, MS-073. Cancer Res. 1991
May 1;51(9):2420-4. PubMed PMID: 1673087.