MS-073

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406780

CAS#: 129716-45-6

Description: MS-073, also known as CP-162398, is a P-glycoprotein inhibitor (P-gp). MS-073 was compared with verapamil with regard to its ability to overcome MDR in vitro and in vivo. MS-073 at 0.1 microM almost completely reversed in vitro resistance to vincristine (VCR) in VCR-resistant P388 cells. MS-073 also reversed in vitro VCR, adriamycin (ADM), etoposide, and actinomycin D resistance in ADM-resistant human myelogenous leukemia K562 (K562/ADM) cells, MS-073 reverses MDR by competitively inhibiting drug binding to P-glycoprotein.


Chemical Structure

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MS-073
CAS# 129716-45-6

Theoretical Analysis

MedKoo Cat#: 406780
Name: MS-073
CAS#: 129716-45-6
Chemical Formula: C31H33N3O2
Exact Mass: 479.2573
Molecular Weight: 479.624
Elemental Analysis: C, 77.63; H, 6.94; N, 8.76; O, 6.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MS-073; MS073; MS 073; CP-162398; CP162398; CP 162398.

IUPAC/Chemical Name: 1-(Quinolin-5-yloxy)-3-[4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten)-5-yl]piperazin-1-yl]-2-propanol

InChi Key: YLQSXCMKFKBZLE-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H33N3O2/c35-25(22-36-30-13-5-12-29-28(30)11-6-16-32-29)21-33-17-19-34(20-18-33)31-26-9-3-1-7-23(26)14-15-24-8-2-4-10-27(24)31/h1-13,16,25,31,35H,14-15,17-22H2

SMILES Code: OC(CN1CCN(C2C3=CC=CC=C3CCC4=CC=CC=C24)CC1)COC5=C6C=CC=NC6=CC=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 479.624 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Smith BJ, Doran AC, McLean S, Tingley FD 3rd, O'Neill BT, Kajiji SM.
P-glycoprotein efflux at the blood-brain barrier mediates differences in brain
disposition and pharmacodynamics between two structurally related neurokinin-1
receptor antagonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1252-9. PubMed PMID:
11504828.

2: Sato W, Fukazawa N, Suzuki T, Yusa K, Tsuruo T. Circumvention of multidrug
resistance by a newly synthesized quinoline derivative, MS-073. Cancer Res. 1991
May 1;51(9):2420-4. PubMed PMID: 1673087.