Nitromifene Citrate
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Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525760

CAS#: 5863-35-4

Description: Nitromifene Citrate A non-steroidal estrogen antagonist (as the 1:1 citrate) most commonly used as a research tool in animal studies.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 500 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-25. Prices are subject to change without notice.

Nitromifene Citrate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525760
Name: Nitromifene Citrate
CAS#: 5863-35-4
Chemical Formula: C33H36N2O11
Exact Mass: 636.23191
Molecular Weight: 636.654
Elemental Analysis: C, 62.26; H, 5.70; N, 4.40; O, 27.64


Synonym: CI-628 citrate; CI628 citrate; CI 628 citrate; Parke davis CI-628; Nitromifene Citrate

IUPAC/Chemical Name: (Z)-1-(2-(4-(1-(4-methoxyphenyl)-2-nitro-2-phenylvinyl)phenoxy)ethyl)pyrrolidine 2-hydroxypropane-1,2,3-tricarboxylate

InChi Key: LHAPNDAERSFWSC-JTHROIFXSA-N

InChi Code: InChI=1S/C27H28N2O4.C6H8O7/c1-32-24-13-9-21(10-14-24)26(27(29(30)31)23-7-3-2-4-8-23)22-11-15-25(16-12-22)33-20-19-28-17-5-6-18-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h2-4,7-16H,5-6,17-20H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b27-26-;

SMILES Code: O=[N+](/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN3CCCC3)C=C2)/C4=CC=C(OC)C=C4)[O-].O=C(CC(C(O)=O)(O)CC(O)=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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2: Nakamura NH, McEwen BS. Changes in interneuronal phenotypes regulated by estradiol in the adult rat hippocampus: a potential role for neuropeptide Y. Neuroscience. 2005;136(1):357-69. Epub 2005 Sep 28. PubMed PMID: 16198490.
3: Rudick CN, Woolley CS. Selective estrogen receptor modulators regulate phasic activation of hippocampal CA1 pyramidal cells by estrogen. Endocrinology. 2003 Jan;144(1):179-87. PubMed PMID: 12488344.
4: Young EA, Altemus M, Parkison V, Shastry S. Effects of estrogen antagonists and agonists on the ACTH response to restraint stress in female rats. Neuropsychopharmacology. 2001 Dec;25(6):881-91. PubMed PMID: 11750181.
5: McEwen BS, Tanapat P, Weiland NG. Inhibition of dendritic spine induction on hippocampal CA1 pyramidal neurons by a nonsteroidal estrogen antagonist in female rats. Endocrinology. 1999 Mar;140(3):1044-7. PubMed PMID: 10067823.
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12: Ruenitz PC, Thompson CB, Srivatsan V. Characterization of MCF 7 breast cancer cell growth inhibition by the antiestrogen nitromifene (CI 628) and selected metabolites. J Steroid Biochem. 1989 Sep;33(3):365-9. PubMed PMID: 2550704.
13: Dumesic DA, Renk M, Kamel F. Estrogenic effects of phenol red on rat pituitary cell responsiveness to gonadotropin-releasing hormone. Life Sci. 1989;44(6):397-406. PubMed PMID: 2645497.
14: Fargin A, Faye JC, le Maire M, Bayard F, Potier M, Beauregard G. Solubilization of a tamoxifen-binding protein. Assessment of its molecular mass. Biochem J. 1988 Nov 15;256(1):229-36. PubMed PMID: 3066343; PubMed Central PMCID: PMC1135392.
15: Pasqualini JR, Sumida C, Giambiagi N. Pharmacodynamic and biological effects of anti-estrogens in different models. J Steroid Biochem. 1988 Oct;31(4B):613-43. Review. PubMed PMID: 3059059.
16: Huet YM, Dey SK. A paradoxical effect of an antiestrogen, CI-628, on implantation in the mouse. Proc Soc Exp Biol Med. 1988 Oct;189(1):61-5. PubMed PMID: 3054903.
17: Borgna JL, Scali J. Differential inhibition of estrogen and antiestrogen binding to the estrogen receptor by diethylpyrocarbonate. J Steroid Biochem. 1988 Oct;31(4A):427-36. PubMed PMID: 3050278.
18: Juriansz RL, Huseby RA, Wilcox RB. Interactions of putative estrogens with the intracellular receptor complex in mouse Leydig cells: relationship to preneoplastic hyperplasia. Cancer Res. 1988 Jan 1;48(1):14-8. PubMed PMID: 3334987.
19: Huet YM, Dey SK. Role of early and late oestrogenic effects on implantation in the mouse. J Reprod Fertil. 1987 Nov;81(2):453-8. PubMed PMID: 3323496.
20: Watts CK, Sutherland RL. Studies on the ligand specificity and potential identity of microsomal antiestrogen-binding sites. Mol Pharmacol. 1987 May;31(5):541-51. PubMed PMID: 3553893.