WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525737
Description: NBI-30545 is a potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility used for stress disorders.
MedKoo Cat#: 525737
Chemical Formula: C22H30N4O3
Exact Mass: 398.23179
Molecular Weight: 398.507
Elemental Analysis: C, 66.31; H, 7.59; N, 14.06; O, 12.04
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Synonym: NBI-30545; NBI30545; NBI 30545
IUPAC/Chemical Name: 3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine
InChi Key: AKFWXFDMKRSYRD-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H30N4O3/c1-7-10-25(11-12-27-4)20-13-15(2)23-22-21(16(3)24-26(20)22)18-9-8-17(28-5)14-19(18)29-6/h8-9,13-14H,7,10-12H2,1-6H3
SMILES Code: CCCN(CCOC)C1=CC(C)=NC2=C(C3=CC=C(OC)C=C3OC)C(C)=NN12
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 398.507 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chen C, Wilcoxen KM, Huang CQ, McCarthy JR, Chen T, Grigoriadis DE.
Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent
corticotropin-releasing factor-1 antagonists with adequate lipophilicity and
water solubility. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3669-73. PubMed PMID: