NBI-30545

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525737

CAS#: 195054-99-0

Description: NBI-30545 is a potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility used for stress disorders.


Chemical Structure

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NBI-30545
CAS# 195054-99-0

Theoretical Analysis

MedKoo Cat#: 525737
Name: NBI-30545
CAS#: 195054-99-0
Chemical Formula: C22H30N4O3
Exact Mass: 398.23179
Molecular Weight: 398.507
Elemental Analysis: C, 66.31; H, 7.59; N, 14.06; O, 12.04

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NBI-30545; NBI30545; NBI 30545

IUPAC/Chemical Name: 3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propylpyrazolo[1,5-a]pyrimidin-7-amine

InChi Key: AKFWXFDMKRSYRD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N4O3/c1-7-10-25(11-12-27-4)20-13-15(2)23-22-21(16(3)24-26(20)22)18-9-8-17(28-5)14-19(18)29-6/h8-9,13-14H,7,10-12H2,1-6H3

SMILES Code: CCCN(CCOC)C1=CC(C)=NC2=C(C3=CC=C(OC)C=C3OC)C(C)=NN12

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 398.507 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chen C, Wilcoxen KM, Huang CQ, McCarthy JR, Chen T, Grigoriadis DE.
Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent
corticotropin-releasing factor-1 antagonists with adequate lipophilicity and
water solubility. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3669-73. PubMed PMID:
15203140.