Naxagolide HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525734

CAS#: 99705-65-4 (HCl)

Description: Naxagolide is a sustained release formulation of a naphthoxazine compound with selective D-2 dopamine receptor agonism. It is a dopamine agonist and an Antiparkinsonian.


Price and Availability

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Naxagolide HCl is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525734
Name: Naxagolide HCl
CAS#: 99705-65-4 (HCl)
Chemical Formula: C15H22ClNO2
Exact Mass: 283.13391
Molecular Weight: 283.796
Elemental Analysis: C, 63.48; H, 7.81; Cl, 12.49; N, 4.94; O, 11.28


Related CAS #: 99705-65-4 (HCl)   88058-88-2 (free base)   100935-99-7 (S-isomer HCl)    

Synonym: MK-458; MK458; MK 458; L 647,339; Naxagolide hydrochloride; Naxagolide HCl

IUPAC/Chemical Name: (4aR,10bR)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride

InChi Key: NNEACMQMRLNNIL-CTHHTMFSSA-N

InChi Code: InChI=1S/C15H21NO2.ClH/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16;/h3,5,10,14-15,17H,2,4,6-9H2,1H3;1H/t14-,15-;/m1./s1

SMILES Code: OC1=CC2=C(C=C1)CC[C@]3([H])[C@]2([H])OCCN3CCC.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Narendran R, Slifstein M, Guillin O, Hwang Y, Hwang DR, Scher E, Reeder S, Rabiner E, Laruelle M. Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo. Synapse. 2006 Dec 1;60(7):485-95. PubMed PMID: 16952157.
2: Belluzzi JD, Domino EF, May JM, Bankiewicz KS, McAfee DA. N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov Disord. 1994 Mar;9(2):147-54. PubMed PMID: 7910948.