Nantradol HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525729

CAS#: 65511-42-4

Description: Nantradol HCl is a potent analgesic and widely used in research into the potential therapeutic applications of cannabinoids.

Price and Availability




Nantradol HCl is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 525729
Name: Nantradol HCl
CAS#: 65511-42-4
Chemical Formula: C27H36ClNO4
Exact Mass: 473.23329
Molecular Weight: 474.038
Elemental Analysis: C, 68.41; H, 7.66; Cl, 7.48; N, 2.95; O, 13.50

Synonym: UM1159; UM 1159; UM-1159; MCV 4161; MCV4161; MCV-4161; Nantradol Hydrochloride; Nantradol HCl

IUPAC/Chemical Name: 9-hydroxy-6-methyl-3-((5-phenylpentan-2-yl)oxy)-5,6,6a,7,8,9,10,10a-octahydrophenanthridin-1-yl acetate hydrochloride


InChi Code: InChI=1S/C27H35NO4.ClH/c1-17(8-7-11-20-9-5-4-6-10-20)31-22-15-25-27(26(16-22)32-19(3)29)24-14-21(30)12-13-23(24)18(2)28-25;/h4-6,9-10,15-18,21,23-24,28,30H,7-8,11-14H2,1-3H3;1H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Smith JB. Situational specificity of tolerance to decreased operant responding by morphine and l-nantradol. Psychopharmacology (Berl). 1991;103(1):115-20. PubMed PMID: 2006237.
2: Smith JB. Effects of fixed-interval duration on the development of tolerance to decreased responding by l-nantradol. Psychopharmacology (Berl). 1987;91(1):127-30. PubMed PMID: 3103154.
3: Smith JB. Effects of fixed-ratio length on the development of tolerance to decreased responding by l-nantradol. Psychopharmacology (Berl). 1986;90(2):259-62. PubMed PMID: 3097708.
4: Smith JB. Effects of single and repeated daily injections of morphine, clonidine and l-nantradol on responding of squirrel monkeys under escape titration. J Pharmacol Exp Ther. 1985 Jul;234(1):94-9. PubMed PMID: 4009508.
5: Smith JB. Effects of single and repeated daily injections of morphine, clonidine, and l-nantradol on avoidance responding of rats. Psychopharmacology (Berl). 1985;87(4):425-9. PubMed PMID: 3936101.
6: Colasanti BK. Intraocular pressure, ocular toxicity and neurotoxicity in response to 11-hydroxy-delta 9-tetrahydrocannabinol and 1-nantradol. J Ocul Pharmacol. 1985 Summer;1(2):123-35. PubMed PMID: 2851633.
7: Howlett AC. Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds. Life Sci. 1984 Oct 22;35(17):1803-10. PubMed PMID: 6090851.
8: Horne WC. Desacetyl-1-nantradol: a selective prostaglandin antagonist. Prostaglandins Leukot Med. 1984 Jul;15(1):129-36. PubMed PMID: 6147860.
9: Dykstra LA. Electric shock titration in squirrel monkeys following administration of nantradol, levonantradol, or N-methyl levonantradol. Psychopharmacology (Berl). 1983;79(4):322-4. PubMed PMID: 6407046.
10: Shepard RM, Milne GM. The use of high-pressure liquid chromatography with electrochemical detection for the assay of nantradol and its application to delta 9- tetrahydrocannabinol. NIDA Res Monogr. 1982;42:7-18. PubMed PMID: 6294527.
11: McIlhenny HM, Mast RW, Johnson MR, Milne GM. Nantradol hydrochloride: pharmacokinetics and behavioral effects after acute and chronic treatment. J Pharmacol Exp Ther. 1981 Nov;219(2):363-9. PubMed PMID: 7288626.
12: Lal H, Bennett DA, Shearman GT, McCarten MD, Murphy R, Angeja A. Effectiveness of nantradol in blocking narcotic withdrawal signs through nonnarcotic mechanisms. J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):361S-366S. PubMed PMID: 7197691.
13: Young AM, Katz JL, Woods JH. Behavioral effects of levonantradol and nantradol in the rhesus monkey. J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):348S-360S. PubMed PMID: 6271836.
14: Gilbert PE. A comparison of THC, nantradol, nabilone, and morphine in the chronic spinal dog. J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):311S-319S. PubMed PMID: 6271835.
15: Milne GM, Koe BK, Johnson MR. Stereospecific and potent analgetic activity for nantradol--a structurally novel, cannabinoid-related analgetic. NIDA Res Monogr. 1979;27:84-92. PubMed PMID: 121368.