WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525725

CAS#: 1491-41-4

Description: Naftalofos is an insecticide and an anthelmintic. Naftalofos represents an effective therapeutic alternative for incorporation into worm control programmes.

Price and Availability


USD 310


Naftalofos, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 525725
Name: Naftalofos
CAS#: 1491-41-4
Chemical Formula: C16H16NO6P
Exact Mass: 349.07152
Molecular Weight: 349.27876
Elemental Analysis: C, 55.02; H, 4.62; N, 4.01; O, 27.48; P, 8.87

Synonym: Maretin; Naftalofosum; Naphthalophos; Rametin; Rawetin; Naftalofos

IUPAC/Chemical Name: 1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl diethyl phosphate


InChi Code: InChI=1S/C16H16NO6P/c1-3-21-24(20,22-4-2)23-17-15(18)12-9-5-7-11-8-6-10-13(14(11)12)16(17)19/h5-10H,3-4H2,1-2H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Kotze AC, Ruffell AP, Ingham AB. Phenobarbital induction and chemical synergism demonstrate the role of UDP-glucuronosyltransferases in detoxification of naphthalophos by Haemonchus contortus larvae. Antimicrob Agents Chemother. 2014 Dec;58(12):7475-83. doi: 10.1128/AAC.03333-14. Epub 2014 Oct 6. PubMed PMID: 25288079; PubMed Central PMCID: PMC4249576.
2: Fiel C, Guzmán M, Steffan P, Rodriguez E, Prieto O, Bhushan C. The efficacy of trichlorphon and naphthalophos against multiple anthelmintic-resistant nematodes of naturally infected sheep in Argentina. Parasitol Res. 2011 Aug;109 Suppl 1:S139-48. doi: 10.1007/s00436-011-2410-8. PubMed PMID: 21739383.
3: Kotze AC, Stein PA, Dobson RJ. Investigation of intestinal nematode responses to naphthalophos and pyrantel using a larval development assay. Int J Parasitol. 1999 Jul;29(7):1093-9. PubMed PMID: 10501619.
4: Cooper NA, Rolfe PF, Searson JE, Dawson KL. Naphthalophos combinations with benzimidazoles or levamisole as effective anthelmintics for sheep. Aust Vet J. 1996 Sep;74(3):221-4. PubMed PMID: 8894038.
5: Le Jambre LF, Barger IA. Efficiency of rafoxanide and naphthalophos against inhibited Haemonchus contortus. Aust Vet J. 1979 Jul;55(7):346-7. PubMed PMID: 518438.
6: Varshney TR, Singh YP. A comparative sutdy of anthelmintic effect of naphthalophos and parbendazole against natural infection of gastro-intestinal worms of sheep. Indian Vet J. 1979 Mar;56(3):207-10. PubMed PMID: 582588.
7: Leland SE Jr, Ridley RK, Dick JW, Slonka GF, Zimmerman GL. Anthelmintic activity of trichlorfon, coumaphos, and naphthalophos against the in vitro grown parastic stages of Cooperia punctata. J Parasitol. 1971 Dec;57(6):1190-6. PubMed PMID: 5157153.
8: Mullee MT, Cox DD, Allen AD. Effect of naphthalophos, phenothiazine, and thiabendazole on gastrointestinal nematode egg counts in feedlot cattle. Am J Vet Res. 1970 Jul;31(7):1203-15. PubMed PMID: 5447693.
9: Nelson DL, White RG, Mozier JO, Allen AD. Toxicity of larger-than-recommended doses of naphthalophos to cattle, sheep, and goats. Am J Vet Res. 1970 Jan;31(1):199-201. PubMed PMID: 5461126.
10: Partosoedjono S, Drudge JH, Lyons ET, Knapp FW. Evaluation of naphthalophos against Oestrus ovis and a thiabendazole-tolerant strain of Haemonchus contortus in lambs. Am J Vet Res. 1969 Jan;30(1):81-3. PubMed PMID: 5812440.
11: Train CT, White RG, Hansen MF. Efficacy of coumaphos and naphthalophos against nematodes of lambs. Am J Vet Res. 1968 Dec;29(12):2331-5. PubMed PMID: 5749116.
12: McDougald LR, White RG, Hansen MF. Efficacy of naphthalophos and coumaphos against nematodes of goats. Am J Vet Res. 1968 May;29(5):1077-9. PubMed PMID: 5646005.