BMS-564929

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406776

CAS#: 627530-84-1

Description: BMS-564929 is a highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator. BMS-564929 is a subnanomolar AR agonist in vitro, is highly selective for the AR vs. other steroid hormone receptors, and exhibits no significant interactions with SHBG or aromatase. Dose response studies in castrated male rats show that BMS-564929 is substantially more potent than testosterone (T) in stimulating the growth of the levator ani muscle, and unlike T, highly selective for muscle vs. prostate.

Chemical Structure

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BMS-564929
CAS# 627530-84-1
Instruction

Theoretical Analysis

MedKoo Cat#: 406776
Name: BMS-564929
CAS#: 627530-84-1
Chemical Formula: C14H12ClN3O3
Exact Mass: 305.06
Molecular Weight: 305.718
Elemental Analysis: C, 55.00; H, 3.96; Cl, 11.60; N, 13.75; O, 15.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BMS-564929; BMS 564929; BMS564929.

IUPAC/Chemical Name: 2-Chloro-3-methyl-4-[(7R,7aS)-tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl]benzonitrile

InChi Key: KEJORAMIZFOODM-PWSUYJOCSA-N

InChi Code: InChI=1S/C14H12ClN3O3/c1-7-9(3-2-8(6-16)11(7)15)18-13(20)12-10(19)4-5-17(12)14(18)21/h2-3,10,12,19H,4-5H2,1H3/t10-,12+/m1/s1

SMILES Code: N#CC1=CC=C(N(C(N2[C@@]3([H])[C@H](O)CC2)=O)C3=O)C(C)=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 305.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Thevis M, Kohler M, Thomas A, Maurer J, Schlörer N, Kamber M, Schänzer W.
Determination of benzimidazole- and bicyclic hydantoin-derived selective androgen
receptor antagonists and agonists in human urine using LC-MS/MS. Anal Bioanal
Chem. 2008 May;391(1):251-61. doi: 10.1007/s00216-008-1882-6. Epub 2008 Feb 13.
PubMed PMID: 18270691.


2: Thevis M, Kohler M, Schlörer N, Kamber M, Kühn A, Linscheid MW, Schänzer W.
Mass spectrometry of hydantoin-derived selective androgen receptor modulators. J
Mass Spectrom. 2008 May;43(5):639-50. PubMed PMID: 18095383.


3: Ostrowski J, Kuhns JE, Lupisella JA, Manfredi MC, Beehler BC, Krystek SR Jr,
Bi Y, Sun C, Seethala R, Golla R, Sleph PG, Fura A, An Y, Kish KF, Sack JS,
Mookhtiar KA, Grover GJ, Hamann LG. Pharmacological and x-ray structural
characterization of a novel selective androgen receptor modulator: potent
hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in
rats. Endocrinology. 2007 Jan;148(1):4-12. Epub 2006 Sep 28. PubMed PMID:
17008401.