CX546

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524918

CAS#: 215923-54-9

Description: CX546 is an AMPA receptor potentiator. It binds specifically to the agonist bound non-desensitized receptor, and most likely destabilizing the desensitized receptor conformation. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.


Chemical Structure

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CX546
CAS# 215923-54-9

Theoretical Analysis

MedKoo Cat#: 524918
Name: CX546
CAS#: 215923-54-9
Chemical Formula: C14H17NO3
Exact Mass: 247.12
Molecular Weight: 247.290
Elemental Analysis: C, 68.00; H, 6.93; N, 5.66; O, 19.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CX546; CX 546; CX-546; UNII-PV6YEC8983; GR 87; GR-87; BDP 17; BDP-17.

IUPAC/Chemical Name: 2,3-Dihydro-1,4-benzodioxin-7-yl-(1-piperidyl)methanone

InChi Key: LJUNPHMOGNFFOS-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2

SMILES Code: c1cc2c(cc1C(=O)N3CCCCC3)OCCO2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 247.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cavalla D, Chianelli F, Korsak A, Hosford PS, Gourine AV, Marina N. Tianeptine prevents respiratory depression without affecting analgesic effect of opiates in conscious rats. Eur J Pharmacol. 2015 Aug 15;761:268-72. doi: 10.1016/j.ejphar.2015.05.067. Epub 2015 Jun 8. PubMed PMID: 26068549.

2: Chang PK, Prenosil GA, Verbich D, Gill R, McKinney RA. Prolonged ampakine exposure prunes dendritic spines and increases presynaptic release probability for enhanced long-term potentiation in the hippocampus. Eur J Neurosci. 2014 Sep;40(5):2766-76. doi: 10.1111/ejn.12638. Epub 2014 Jun 13. PubMed PMID: 24925283.

3: Modvig A, Andersen TL, Taaning RH, Lindhardt AT, Skrydstrup T. Two-chamber hydrogen generation and application: access to pressurized deuterium gas. J Org Chem. 2014 Jun 20;79(12):5861-8. doi: 10.1021/jo500801t. Epub 2014 Jun 11. PubMed PMID: 24870212.

4: O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. Review. PubMed PMID: 17504104.

5: O'Neill MJ, Bleakman D, Zimmerman DM, Nisenbaum ES. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94. Review. PubMed PMID: 15180479.