BAY65-1942 free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406773

CAS#: 600734-02-9

Description: BAY65-1942 is an ATP-competitive inhibitor that selectively targets IKKbeta kinase activity. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury.

Price and Availability




BAY65-1942 free base purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 406773
Name: BAY65-1942 free base
CAS#: 600734-02-9
Chemical Formula: C22H25N3O4
Exact Mass: 395.1845
Molecular Weight: 395.459
Elemental Analysis: C, 66.82; H, 6.37; N, 10.63; O, 16.18

Synonym: BAY 65-1942; BAY-65-1942; BAY65-1942; BAY 651942; BAY-651942; BAY651942. BAY65-1942 free base.

IUPAC/Chemical Name: (S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one


InChi Code: InChI=1S/C22H25N3O4/c26-18-4-1-5-19(28-11-13-6-7-13)20(18)17-9-15(14-3-2-8-23-10-14)16-12-29-22(27)25-21(16)24-17/h1,4-5,9,13-14,23,26H,2-3,6-8,10-12H2,(H,24,25,27)/t14-/m1/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Cooper MJ, Cox NJ, Zimmerman EI, Dewar BJ, Duncan JS, Whittle MC, Nguyen TA,
Jones LS, Ghose Roy S, Smalley DM, Kuan PF, Richards KL, Christopherson RI, Jin
J, Frye SV, Johnson GL, Baldwin AS, Graves LM. Application of multiplexed kinase
inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One.
2013 Jun 24;8(6):e66755. doi: 10.1371/journal.pone.0066755. Print 2013. PubMed
PMID: 23826126; PubMed Central PMCID: PMC3691232.

2: Harken AH. The world of inhibitory kappaB. Am J Physiol Heart Circ Physiol.
2007 Nov;293(5):H2624-5. Epub 2007 Sep 7. PubMed PMID: 17827258.

3: Moss NC, Stansfield WE, Willis MS, Tang RH, Selzman CH. IKKbeta inhibition
attenuates myocardial injury and dysfunction following acute ischemia-reperfusion
injury. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53. Epub 2007 Aug
3. PubMed PMID: 17675566.