UK 1745

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526520

CAS#: 170684-14-7

Description: UK 1745 is a novel cardiotonic drug.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-22. Prices are subject to change without notice.

UK 1745 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526520
Name: UK 1745
CAS#: 170684-14-7
Chemical Formula: C16H23ClN2O2
Exact Mass: 310.1448
Molecular Weight: 310.822
Elemental Analysis: C, 61.83; H, 7.46; Cl, 11.41; N, 9.01; O, 10.29


Synonym: UK 1745, UK1745, UK-1745

IUPAC/Chemical Name: (2R,3S)-2-(aminomethyl)-2,3,5,8,8-pentamethyl-2,3,6,8-tetrahydro-7H-furo[2,3-e]indol-7-one hydrochloride

InChi Key: XVUOIQVVCCRMAY-SCKAJQSLSA-N

InChi Code: InChI=1S/C16H22N2O2.ClH/c1-8-6-10-9(2)16(5,7-17)20-13(10)11-12(8)18-14(19)15(11,3)4;/h6,9H,7,17H2,1-5H3,(H,18,19);1H/t9-,16-;/m0./s1

SMILES Code: O=C1NC2=C(C(O[C@@](C)(CN)[C@H]3C)=C3C=C2C)C1(C)C.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Uemura H, Sakamoto N, Nakaya H. Electropharmacological effects of UK-1745, a novel cardiotonic drug, in guinea-pig ventricular myocytes. Eur J Pharmacol. 1999 Nov 3;383(3):361-71. PubMed PMID: 10594330.

2: Sawada H, Endoh M. Pharmacological characterization of effects of UK-1745, a novel cardiotonic agent with beta-adrenoceptor-blocking action, in aequorin-loaded canine right ventricular muscle. J Mol Cell Cardiol. 1999 May;31(5):1047-62. PubMed PMID: 10336843.

3: Uchida Y, Kawada M, Sawanobori K, Sonoki H, Inoue K, Mizuno K, Itou T, Tabunoki Y, Tsukamoto M, Ohashi Y, Kyotani Y, Shimizu N, Fujii M, Nakamura M. Cardiovascular effects of (2RS,3SR)- 2-aminomethyl-2,3,7,8-tetrahydro-2,3,5,8,8-pentamethyl-6H-furo- [2,3-e]indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties. Arzneimittelforschung. 1998 Mar;48(3):219-31. PubMed PMID: 9553677.