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AIM-100
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406771

CAS#: 873305-35-2

Description: AIM-100 is a potent and selective Ack1 tyrosine kinase with IC50 value of 24 nM. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 550 2 Weeks
200mg USD 850 2 Weeks
500mg USD 1850 2 Weeks
1g USD 2950 2 Weeks
2g USD 4850 2 Weeks
5g USD 7950 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-01-24. Prices are subject to change without notice.

AIM-100, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406771
Name: AIM-100
CAS#: 873305-35-2
Chemical Formula: C23H21N3O2
Exact Mass: 371.1634
Molecular Weight: 371.44
Elemental Analysis: C, 74.37; H, 5.70; N, 11.31; O, 8.61


Synonym: AIM-100; AIM 100; AIM100.

IUPAC/Chemical Name: N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine

InChi Key: XNFHHOXCDUAYSR-SFHVURJKSA-N

InChi Code: InChI=1S/C23H21N3O2/c1-3-8-16(9-4-1)19-20-22(24-14-18-12-7-13-27-18)25-15-26-23(20)28-21(19)17-10-5-2-6-11-17/h1-6,8-11,15,18H,7,12-14H2,(H,24,25,26)/t18-/m0/s1

SMILES Code: C12=NC=NC(NC[C@H]3OCCC3)=C1C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Mahajan K, Lawrence HR, Lawrence NJ, Mahajan NP. ACK1 tyrosine kinase
interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene
HOXA1. J Biol Chem. 2014 Oct 10;289(41):28179-91. doi: 10.1074/jbc.M114.584425.
Epub 2014 Aug 22. PubMed PMID: 25148682; PubMed Central PMCID: PMC4192474.

2: Mahajan K, Coppola D, Rawal B, Chen YA, Lawrence HR, Engelman RW, Lawrence NJ,
Mahajan NP. Ack1-mediated androgen receptor phosphorylation modulates radiation
resistance in castration-resistant prostate cancer. J Biol Chem. 2012 Jun
22;287(26):22112-22. doi: 10.1074/jbc.M112.357384. Epub 2012 May 7. PubMed PMID:
22566699; PubMed Central PMCID: PMC3381169.

3: Mahajan K, Coppola D, Chen YA, Zhu W, Lawrence HR, Lawrence NJ, Mahajan NP.
Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am
J Pathol. 2012 Apr;180(4):1386-93. doi: 10.1016/j.ajpath.2011.12.028. Epub 2012
Feb 7. PubMed PMID: 22322295; PubMed Central PMCID: PMC3349895.

4: Mahajan K, Challa S, Coppola D, Lawrence H, Luo Y, Gevariya H, Zhu W, Chen YA,
Lawrence NJ, Mahajan NP. Effect of Ack1 tyrosine kinase inhibitor on
ligand-independent androgen receptor activity. Prostate. 2010 Sep
1;70(12):1274-85. doi: 10.1002/pros.21163. PubMed PMID: 20623637; PubMed Central
PMCID: PMC3953126.