A-438079 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526699

CAS#: 899431-18-6 (HCl)

Description: A-438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease.

Chemical Structure

A-438079 HCl
CAS# 899431-18-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 526699
Name: A-438079 HCl
CAS#: 899431-18-6 (HCl)
Chemical Formula: C13H10Cl3N5
Exact Mass:
Molecular Weight: 342.608
Elemental Analysis: C, 45.57; H, 2.94; Cl, 31.04; N, 20.44

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
10.0mg USD 450.0 2 Weeks
25.0mg USD 750.0 2 Weeks
50.0mg USD 1250.0 2 Weeks
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Related CAS #: 899431-18-6 (HCl)   899507-36-9 (free base)  

Synonym: A-438079 ; A 438079; A438079; A-438079 HCl.

IUPAC/Chemical Name: 3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride


InChi Code: InChI=1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 342.608 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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