PRX-08066 free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526697

CAS#: 866206-54-4

Description: PRX-08066 is a a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. In the 5-HT(2B) expressing SI-NET cell line, KRJ-I, PRX-08066 inhibited proliferation (IC(50) 4.6 x 10(-9)M) and 5-HT secretion (6.9 x 10(-9)M) and decreased ERK1/2 phosphorylation and profibrotic growth factor synthesis and secretion (transforming growth factor beta 1 [TGFbeta1], connective tissue growth factor [CTGF] and fibroblast growth factor [FGF2]).

Chemical Structure

PRX-08066 free base
CAS# 866206-54-4

Theoretical Analysis

MedKoo Cat#: 526697
Name: PRX-08066 free base
CAS#: 866206-54-4
Chemical Formula: C19H17ClFN5S
Exact Mass: 401.0877
Molecular Weight: 401.8884
Elemental Analysis: C, 56.78; H, 4.26; Cl, 8.82; F, 4.73; N, 17.43; S, 7.98

Price and Availability

Size Price Availability Quantity
100.0mg USD 1350.0 2 Weeks
200.0mg USD 1850.0 2 Weeks
500.0mg USD 2150.0 2 Weeks
1.0g USD 3250.0 2 Weeks
2.0g USD 4250.0 2 Weeks
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Related CAS #: 866206-55-5(PRX-08066 Maleate)  

Synonym: PRX-08066; PRX 08066; PRX08066.

IUPAC/Chemical Name: 5-((4-(6-Chlorothieno(2,3-d)pyrimidine-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile


InChi Code: InChI=1S/C19H17ClFN5S.C4H4O4/c20-17-8-15-18(23-11-24-19(15)27-17)25-14-3-5-26(6-4-14)10-12-1-2-16(21)13(7-12)9-22;5-3(6)1-2-4(7)8/h1-2,7-8,11,14H,3-6,10H2,(H,23,24,25);1-2H,(H,5,6)(H,7,8)/b;2-1-


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 401.8884 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kim SK, Li Y, Abrol R, Heo J, Goddard WA 3rd. Predicted structures and
dynamics for agonists and antagonists bound to serotonin 5-HT2B and 5-HT2C
receptors. J Chem Inf Model. 2011 Feb 28;51(2):420-33. doi: 10.1021/ci100375b.
Epub 2011 Feb 7. PubMed PMID: 21299232; PubMed Central PMCID: PMC3070210.

2: Svejda B, Kidd M, Giovinazzo F, Eltawil K, Gustafsson BI, Pfragner R, Modlin
IM. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine
tumor cell proliferation and the modulation of the fibroblast component of the
neoplastic microenvironment. Cancer. 2010 Jun 15;116(12):2902-12. doi:
10.1002/cncr.25049. PubMed PMID: 20564397.

3: Porvasnik SL, Germain S, Embury J, Gannon KS, Jacques V, Murray J, Byrne BJ,
Shacham S, Al-Mousily F. PRX-08066, a novel 5-hydroxytryptamine receptor 2B
antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and
right ventricular hypertrophy in rats. J Pharmacol Exp Ther. 2010
Aug;334(2):364-72. doi: 10.1124/jpet.109.165001. Epub 2010 Apr 29. PubMed PMID:

4: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin
Pharmacol. 2008 Sep;30(7):543-88. PubMed PMID: 18985183.