Zaltidine

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MedKoo CAT#: 526579

CAS#: 85604-00-8 (free base)

Description: Zaltidine, also known as CP-57,361, is an effective but hepatotoxic H2-receptor antagonist. Zaltidine appears to be an effective treatment of duodenal ulcer. However, the incidence of hepatic damage (8%) seems higher than with commonly used H2-receptor antagonists.


Chemical Structure

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Zaltidine
CAS# 85604-00-8 (free base)

Theoretical Analysis

MedKoo Cat#: 526579
Name: Zaltidine
CAS#: 85604-00-8 (free base)
Chemical Formula: C8H10N6S
Exact Mass: 222.0688
Molecular Weight: 222.27
Elemental Analysis: C, 43.23; H, 4.54; N, 37.81; S, 14.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 85604-00-8 (free base)   90274-23-0 (HCl)    

Synonym: Zaltidine; CP-57,361; CP 57,361; CP57,361; CP-57361; CP 57361; CP57361;CP-57361-01.

IUPAC/Chemical Name: 1-(4-(2-methyl-1H-imidazol-4-yl)thiazol-2-yl)guanidine

InChi Key: GIMNAEMRNXUAQP-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H10N6S/c1-4-11-2-5(12-4)6-3-15-8(13-6)14-7(9)10/h2-3H,1H3,(H,11,12)(H4,9,10,13,14)

SMILES Code: NC(NC1=NC(C2=CNC(C)=N2)=CS1)=N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 222.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Farup PG. Zaltidine: an effective but hepatotoxic H2-receptor antagonist. Scand J Gastroenterol. 1988 Aug;23(6):655-8. PubMed PMID: 2902681.

2: Laferla G, Buchanan N, Hearns J, Crean GP, McColl KE, Clucas AT. The antisecretory effects of zaltidine, a novel long-acting H2-receptor antagonist, in healthy volunteers and in subjects with a past history of duodenal ulcer. Br J Clin Pharmacol. 1986 Oct;22(4):395-9. PubMed PMID: 2876724; PubMed Central PMCID: PMC1401146.

3: Hunter RP, Canning PC, Hassfurther R. Plasma analysis and pharmacokinetics of zaltidine, an H2-antagonist, in cattle after intravenous, intramuscular, subcutaneous, and oral administration. J Vet Pharmacol Ther. 1996 Aug;19(4):326-8. PubMed PMID: 8866466.



Additional Information

Related CAS#
85604-00-8 (Zaltidine free base)
90274-23-0 (Zaltidine hydrochloride)