T-0201

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526689

CAS#: 169679-53-2

Description: T-0201, also known as TA 0201, is a highly potent, long-lasting, orally active and selective ETA receptor antagonist.. In binding studies, T-0201 competitively antagonized the specific binding of [125I]-ET-1 to human cloned ETA receptors (the Ki value was 0.015 +/- 0.004 nM). T-0201 weakly inhibited [125I]-ET-1-binding to human cloned ETB receptors; the Ki value was 41 +/- 21 nM. T-0201 also caused the inhibition of ET-1-induced contraction of the isolated rabbit pulmonary artery (pA2 = 5.7 +/- 0.3).


Chemical Structure

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T-0201
CAS# 169679-53-2

Theoretical Analysis

MedKoo Cat#: 526689
Name: T-0201
CAS#: 169679-53-2
Chemical Formula: C27H28BrN5O5S
Exact Mass: 613.0995
Molecular Weight: 614.515
Elemental Analysis: C, 52.77; H, 4.59; Br, 13.00; N, 11.40; O, 13.02; S, 5.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 169679-53-2   188307-16-6 (sodium salt)  

Synonym: T-0201, T0201, T 0201, TA 0201, TA0201, TA-0201

IUPAC/Chemical Name: N-(6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-5-(p-tolyl)pyrimidin-4-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzenesulfonamide

InChi Key: YAWNVAQKVARTGQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H28BrN5O5S/c1-18-4-6-19(7-5-18)23-24(33-39(35,36)22-10-8-20(9-11-22)27(2,3)16-34)31-17-32-25(23)37-12-13-38-26-29-14-21(28)15-30-26/h4-11,14-15,17,34H,12-13,16H2,1-3H3,(H,31,32,33)

SMILES Code: CC(CO)(C)C1=CC=C(S(NC2=NC=NC(OCCOC3=NC=C(Br)C=N3)=C2C4=CC=C(C)C=C4)(=O)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 614.515 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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