WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406765
CAS#: 1190379-70-4 (HCl)
Description: MRT67307 is a potent ULK inhibitor and SIK inhibitor. MRT67307 potently inhibits ULK1 and ULK2 in vitro and block autophagy in cells. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.
MedKoo Cat#: 406765
Name: MRT67307 HCl
CAS#: 1190379-70-4 (HCl)
Chemical Formula: C27H38Cl2N4O
Molecular Weight: 505.528
Elemental Analysis: C, 64.15; H, 7.58; Cl, 14.02; N, 11.08; O, 3.16
Related CAS #: 1190379-70-4 (HCl) 1190378-57-4 (free base)
Synonym: MRT67307; MRT-67307; MRT 67307; MRT67307 HCl. MRT67307 hydrochloride
IUPAC/Chemical Name: N-(3-((2-cyclopropyl-5-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)phenyl)amino)propyl)cyclobutanecarboxamide dihydrochloride
InChi Key: AVTUJIVDDXSHKB-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H36N4O.2ClH/c1-31-15-12-21-16-23(9-8-22(21)18-31)30-24-10-11-25(19-6-7-19)26(17-24)28-13-3-14-29-27(32)20-4-2-5-20;;/h8-11,16-17,19-20,28,30H,2-7,12-15,18H2,1H3,(H,29,32);2*1H
SMILES Code: O=C(C1CCC1)NCCCNC2=CC(NC3=CC4=C(CN(C)CC4)C=C3)=CC=C2C5CC5.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 505.528 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Petherick KJ, Conway OJ, Mpamhanga C, Osborne SA, Kamal A, Saxty B, Ganley IG.
Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin
(mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. doi:
10.1074/jbc.C114.627778. Epub 2015 Apr 1. Erratum in: J Biol Chem. 2015 Nov
27;290(48):28726. PubMed PMID: 25833948; PubMed Central PMCID: PMC4416842.
2: Clark K, MacKenzie KF, Petkevicius K, Kristariyanto Y, Zhang J, Choi HG,
Peggie M, Plater L, Pedrioli PG, McIver E, Gray NS, Arthur JS, Cohen P.
Phosphorylation of CRTC3 by the salt-inducible kinases controls the
interconversion of classically activated and regulatory macrophages. Proc Natl
Acad Sci U S A. 2012 Oct 16;109(42):16986-91. doi: 10.1073/pnas.1215450109. Epub
2012 Oct 2. PubMed PMID: 23033494; PubMed Central PMCID: PMC3479463.
3: Clark K, Peggie M, Plater L, Sorcek RJ, Young ER, Madwed JB, Hough J, McIver
EG, Cohen P. Novel cross-talk within the IKK family controls innate immunity.
Biochem J. 2011 Feb 15;434(1):93-104. doi: 10.1042/BJ20101701. PubMed PMID:
CAS#1190379-70-4 ( MRT67307HCl);
CAS#1190378-57-4 ( MRT67307 free base)
Autophagy is a cell-protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of autophagy to help them to cope with the stress of tumorigenesis; thus targeting autophagy is an attractive therapeutic approach