Landiolol HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326680

CAS#: 144481-98-1 (HCl)

Description: Landiolol, also known as LDLL600 and ONO 1101, is an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis. Landiolol is a drug which acts as a highly cardioselective, ultra short-acting beta blocker. It is used as an anti-arrhythmic agent. Landiolol reduces hemodynamic responses to bronchoscopy-assisted suctioning in intubated ICU patients.

Chemical Structure

Landiolol HCl
CAS# 144481-98-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 326680
Name: Landiolol HCl
CAS#: 144481-98-1 (HCl)
Chemical Formula: C25H40ClN3O8
Exact Mass: 545.2504
Molecular Weight: 546.058
Elemental Analysis: C, 54.99; H, 7.38; Cl, 6.49; N, 7.70; O, 23.44

Price and Availability

Size Price Availability Quantity
50.0mg USD 250.0 2 Weeks
100.0mg USD 550.0 2 Weeks
250.0mg USD 1050.0 2 Weeks
Bulk inquiry

Related CAS #: 144481-98-1 (HCl)   133242-30-5 (free base)    

Synonym: LDLL600; LDLL 600; LDLL-600; ONO1101; ONO-1101; ONO 1101 hydrochloride; Landiolol; Landiolol HCl; Landiolol hydrochloride.

IUPAC/Chemical Name: (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate hydrochloride


InChi Code: InChI=1S/C25H39N3O8.ClH/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28;/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31);1H/t20-,22?;/m0./s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 546.058 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Wada Y, Aiba T, Tsujita Y, Itoh H, Wada M, Nakajima I, Ishibashi K, Okamura H, Miyamoto K, Noda T, Sugano Y, Kanzaki H, Anzai T, Kusano K, Yasuda S, Horie M, Ogawa H. Practical applicability of landiolol, an ultra-short-acting β1-selective blocker, for rapid atrial and ventricular tachyarrhythmias with left ventricular dysfunction. J Arrhythm. 2016 Apr;32(2):82-8. doi: 10.1016/j.joa.2015.09.002. Epub 2015 Nov 2. PubMed PMID: 27092187; PubMed Central PMCID: PMC4823575.

2: Takata J, Haruyama N, Arashi T, Mae T. Alteration of fatal 1:1 conducted atrial flutter to less conducted ratio by landiolol infusion. J Anesth. 2016 Apr 16. [Epub ahead of print] PubMed PMID: 27085543.

3: Kido T, Mochizuki T, Hirano M, Yamada Y, Tanaka R, Kanzaki S, Higashi M, Jinzaki M, Yoshioka K, Kuribayashi S. Radiation-Dose-Lowering Effects of Landiolol Hydrochloride in Coronary Angiography Using Computed Tomography (DELIGHT) - A Prospective Multicenter Study. Circ J. 2016 Apr 25;80(5):1225-31. doi: 10.1253/circj.CJ-15-0962. Epub 2016 Mar 28. PubMed PMID: 27019983.

4: Tachi K, Takahashi S, Tanaka M. [Relationship between the Landiolol Dose and Urinary Catecholamine Metabolites in the Perioperative Management of Patients Undergoing Pheochromocytoma Resection]. Masui. 2015 Dec;64(12):1234-8. Japanese. PubMed PMID: 26790322.

5: Shibata SC, Uchiyama A, Ohta N, Fujino Y. Efficacy and Safety of Landiolol Compared to Amiodarone for the Management of Postoperative Atrial Fibrillation in Intensive Care Patients. J Cardiothorac Vasc Anesth. 2016 Apr;30(2):418-22. doi: 10.1053/j.jvca.2015.09.007. Epub 2015 Sep 25. PubMed PMID: 26703973.

6: Miyake K, Fujita Y, Yoshizawa S, Tomita M, Miyazu M, Sento Y, Yoshimura S, Sobue K. Effects of landiolol on refractory tachyarrhythmia after total cavopulmonary connection: a retrospective, observational, cohort study. J Anesth. 2016 Apr;30(2):331-6. doi: 10.1007/s00540-015-2119-4. Epub 2015 Dec 23. PubMed PMID: 26699148.

7: Ishigaki D, Arimoto T, Iwayama T, Hashimoto N, Kutsuzawa D, Kumagai Y, Nishiyama S, Takahashi H, Shishido T, Miyamoto T, Watanabe T, Kubota I. Prevention of immediate recurrence of atrial fibrillation with low-dose landiolol after radiofrequency catheter ablation. J Arrhythm. 2015 Oct;31(5):279-85. doi: 10.1016/j.joa.2015.02.003. Epub 2015 Apr 4. PubMed PMID: 26550083; PubMed Central PMCID: PMC4600890.

8: Li L, Ai Q, Lin L, Ge P, Yang C, Zhang L. Efficacy and safety of landiolol for prevention of atrial fibrillation after cardiac surgery: a meta-analysis of randomized controlled trials. Int J Clin Exp Med. 2015 Jul 15;8(7):10265-73. eCollection 2015. Review. PubMed PMID: 26379818; PubMed Central PMCID: PMC4565201.

9: Nitta D, Kinugawa K, Imamura T, Endo M, Amiya E, Inaba T, Maki H, Hatano M, Komuro I. An Experience of Landiolol Use for an Advanced Heart Failure Patient With Severe Hypotension. Int Heart J. 2015;56(5):564-7. doi: 10.1536/ihj.15-103. Epub 2015 Sep 11. PubMed PMID: 26370372.

10: Kanamori K, Aoyagi T, Mikamo T, Tsutsui K, Kunishima T, Inaba H, Hayami N, Murakawa Y. Successful Treatment of Refractory Electrical Storm With Landiolol After More Than 100 Electrical Defibrillations. Int Heart J. 2015;56(5):555-7. doi: 10.1536/ihj.15-102. Epub 2015 Sep 4. PubMed PMID: 26346519.

11: Okajima M, Takamura M, Taniguchi T. Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis. World J Crit Care Med. 2015 Aug 4;4(3):251-7. doi: 10.5492/wjccm.v4.i3.251. eCollection 2015 Aug 4. PubMed PMID: 26261777; PubMed Central PMCID: PMC4524822.

12: Sezai A, Osaka S, Yaoita H, Ishii Y, Arimoto M, Hata H, Shiono M. Safety and efficacy of landiolol hydrochloride for prevention of atrial fibrillation after cardiac surgery in patients with left ventricular dysfunction: Prevention of Atrial Fibrillation After Cardiac Surgery With Landiolol Hydrochloride for Left Ventricular Dysfunction (PLATON) trial. J Thorac Cardiovasc Surg. 2015 Oct;150(4):957-64. doi: 10.1016/j.jtcvs.2015.07.003. Epub 2015 Jul 10. PubMed PMID: 26254752.

13: Yamashita Y, Iguchi M, Nakatani R, Usui T, Takagi D, Hamatani Y, Unoki T, Ishii M, Ogawa H, Masunaga N, Abe M, Akao M. Thyroid Storm with Heart Failure Treated with a Short-acting Beta-adrenoreceptor Blocker, Landiolol Hydrochloride. Intern Med. 2015;54(13):1633-7. doi: 10.2169/internalmedicine.54.3138. Epub 2015 Jul 1. PubMed PMID: 26134196.

14: Deguchi S, Komasawa N, Fujiwara S, Kido H, Minami T. [Successful sedation with landiolol and dexmedetomidine during spinal anesthesia in a patient with active dementia]. Masui. 2015 Jan;64(1):95-7. Japanese. PubMed PMID: 25868211.

15: Oka H, Sugimoto M, Azuma H. Efficacy of landiolol for the treatment of junctional ectopic tachycardia resulting from sepsis. Cardiol Young. 2016 Jan;26(1):183-7. doi: 10.1017/S1047951115000244. Epub 2015 Mar 18. PubMed PMID: 25785611.

16: Kunisawa T, Yamagishi A, Suno M, Nakade S, Honda N, Kurosawa A, Sugawara A, Tasaki Y, Iwasaki H. Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in patients with peripheral arterial disease. Ther Clin Risk Manag. 2015 Jan 17;11:107-14. doi: 10.2147/TCRM.S74867. eCollection 2015. PubMed PMID: 25653534; PubMed Central PMCID: PMC4303402.

17: Hifumi T, Kato H, Koido Y, Kawakita K, Kuroda Y. Safety and effective use of landiolol in the ICU. J Intensive Care. 2014 Feb 21;2(1):16. doi: 10.1186/2052-0492-2-16. eCollection 2014. PubMed PMID: 25520832; PubMed Central PMCID: PMC4267602.

18: Tochikubo J, Adachi YU, Ejima T, Numaguchi A, Matsuda N, Sato S, Shiiya N. Landiolol reduces hemodynamic responses to bronchoscopy-assisted suctioning in intubated ICU patients. J Intensive Care. 2014 Jan 23;2(1):6. doi: 10.1186/2052-0492-2-6. eCollection 2014. PubMed PMID: 25520823; PubMed Central PMCID: PMC4267460.

19: Yamashita T, Saitoh T, Matsushita M. Design of a prospective observational survey on landiolol in atrial fibrillation/atrial flutter patients with chronic heart failure - AF-CHF landiolol survey. J Cardiol. 2015 Jul;66(1):69-72. doi: 10.1016/j.jjcc.2014.09.008. Epub 2014 Nov 6. PubMed PMID: 25454208.

20: Niwa Y, Koike M, Iwata N, Kobayashi D, Tanaka C, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y. Effect of landiolol hydrochloride on tachyarrhythmia after esophagectomy. Hepatogastroenterology. 2014 Sep;61(134):1546-51. PubMed PMID: 25436340.