KGA-2727
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526670

CAS#: 666842-36-0

Description: KGA-2727 is a potent and selective SGLT1 inhibitor for the treatment of diabete. KGA-2727 inhibited SGLT1 potently and highly selectively in an in vitro assay using cells transiently expressing recombinant SGLTs. KGA-2727 inhibited the absorption of glucose but not that of fructose. It has inhibition constant (Ki) values of 97 and 13,600 nM for human (h) SGLT1 and hSGLT2, respectively.


Chemical Structure

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KGA-2727
CAS# 666842-36-0

Theoretical Analysis

MedKoo Cat#: 526670
Name: KGA-2727
CAS#: 666842-36-0
Chemical Formula: C26H40N4O8
Exact Mass: 536.28
Molecular Weight: 536.626
Elemental Analysis: C, 58.19; H, 7.51; N, 10.44; O, 23.85

Price and Availability

Size Price Availability Quantity
5mg USD 550 2 Weeks
10mg USD 950 2 Weeks
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Synonym: KGA-2727; KGA 2727; KGA2727.

IUPAC/Chemical Name: 3-(3-{4-[3-(beta-D-glucopyranosyloxy)-5-isopropyl-1Hpyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)propionamide

InChi Key: MDBARDSTXONTFS-MNDUUMEHSA-N

InChi Code: InChI=1S/C26H40N4O8/c1-14(2)21-18(25(30-29-21)38-26-24(35)23(34)22(33)19(13-31)37-26)12-16-5-6-17(11-15(16)3)36-10-4-8-28-9-7-20(27)32/h5-6,11,14,19,22-24,26,28,31,33-35H,4,7-10,12-13H2,1-3H3,(H2,27,32)(H,29,30)/t19-,22-,23+,24-,26+/m1/s1

SMILES Code: O=C(N)CCNCCCOC1=CC=C(CC2=C(C(C)C)NN=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(C)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 536.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dobbins RL, Greenway FL, Chen L, Liu Y, Breed SL, Andrews SM, Wald JA, Walker
A, Smith CD. Selective sodium-dependent glucose transporter 1 inhibitors block
glucose absorption and impair glucose-dependent insulinotropic peptide release.
Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1;308(11):G946-54. doi:
10.1152/ajpgi.00286.2014. Epub 2015 Mar 12. PubMed PMID: 25767259.


2: Shibazaki T, Tomae M, Ishikawa-Takemura Y, Fushimi N, Itoh F, Yamada M, Isaji
M. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose
cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J
Pharmacol Exp Ther. 2012 Aug;342(2):288-96. doi: 10.1124/jpet.112.193045. Epub
2012 Apr 26. PubMed PMID: 22537769.